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Updated: Jun 27, 2026
Deficient Pms2, ERCC1, Ku86, CcOI in Field Defects During Progression to Colon Cancer
Published on: July 28, 2010
Micronucleus analysis in patients with colorectal adenocarcinoma and colorectal polyps
Ali Karaman1, Doğan Nasir Binici, Mehmet Eşref Kabalar
1Erzurum Training and Research Hospital, Department of Medical Genetics, Erzurum 25240, Turkey. alikaramandr@hotmail.com
Aim:
To determine, by counting micronucleus (MN) frequencies, whether chromosomal or DNA damage have an effect on the pathogenesis of early colorectal adenocarcinoma (CRC).
Methods:
We analyzed MN frequencies in 21 patients with CRC, 24 patients with colon polyps [10 neoplastic polyps (NP) and 14 non-neoplastic polyps (NNP)] and 20 normal controls.
Results:
MN frequency was significantly increased in CRC patients and in NP patients compared with controls (3.72 +/- 1.34, 3.58 +/- 1.21 vs 1.97 +/- 0.81, P < 0.001). However, there was no difference in the MN frequency between CRC patients and NP patients (P > 0.05). Similarly, there was no difference in the MN frequency between NNP patients (2.06 +/- 0.85) and controls (P > 0.05).
Conclusion:
Our results suggest increased chromosome/DNA instabilities may be associated with the pathogenesis of early CRC.
