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Simplified Whole Body Plethysmography to Characterize Lung Function During Respiratory Melioidosis
Published on: February 24, 2023
Rheumatological manifestations in patients with melioidosis.
P Teparrakkul1, J J Tsai, W Chierakul
1Medical Department, Sappasithiprasong Hospital, Ubon Ratchathani, Thailand. prapith_11@hotmail.com
The Southeast Asian Journal of Tropical Medicine and Public Health
|December 9, 2008
Summary
Rheumatological melioidosis, an infection by Burkholderia pseudomallei, affects joints, bones, or muscles. This condition, linked to diabetes and thalassemia, shows a longer illness but lower mortality than non-rheumatological melioidosis.
Area of Science:
- Infectious Diseases
- Rheumatology
- Bacteriology
Background:
- Melioidosis, caused by Burkholderia pseudomallei, presents diverse clinical symptoms.
- Rheumatological involvement (joint, bone, muscle) is a significant manifestation of melioidosis.
Purpose of the Study:
- To describe rheumatological melioidosis.
- To compare clinical features and outcomes of patients with and without rheumatological melioidosis.
Main Methods:
- Retrospective study of 679 culture-confirmed melioidosis patients (2002-2005).
- Analysis of 98 patients with rheumatological melioidosis (joint, bone, muscle involvement).
- Comparison of patient demographics, risk factors, clinical course, and mortality.
Main Results:
- 14.4% of melioidosis patients had rheumatological involvement.
- Females, diabetes, and thalassemia were associated with rheumatological melioidosis.
- Rheumatological cases had longer fever clearance and hospitalization but lower mortality.
- Prolonged septic arthritis (>2 weeks) indicated extensive infection, especially in diabetics.
- Surgical intervention improved survival but not infection duration.
Conclusions:
- Rheumatological melioidosis is characterized by a more chronic course and reduced mortality.
- Diabetes and thalassemia are key risk factors for rheumatological melioidosis.
- Early intervention for septic arthritis may prevent extensive bone and muscle infection.
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