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Updated: Jun 27, 2026

Tissue-specific miRNA Expression Profiling in Mouse Heart Sections Using In Situ Hybridization
Published on: September 15, 2018
Changes in regulatory microRNA expression in myocardium of heart failure patients on left ventricular assist device
Marguérite E I Schipper1, Joyce van Kuik, Nicholas de Jonge
1Department of Pathology, University Medical Center Utrecht, Utrecht, The Netherlands.
Background:
Left ventricular assist device support in heart failure patients leads to changes in mRNA and protein expression in the myocardium.
Methods:
MicroRNA's are important regulators of various cellular processes, so changes in their expression were tested by Q-PCR methods.
Results:
LVAD support (independently of the duration) leads to a decrease of the expression of miR-1, miR-133a and miR-133b in DCM patients but to an increase in expression in IHD patients. The expression of miR's pre- and post-LVAD in heart failure patients was low compared to the level of miR's in control myocardial tissue.
Conclusions:
Alterations in miRs expression might also be important during repair processes in IHD patients.
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