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Prosopagnosia01:24

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Related Experiment Video

Updated: Jun 27, 2026

Virtual Reality Tools for Assessing Unilateral Spatial Neglect: A Novel Opportunity for Data Collection
07:04

Virtual Reality Tools for Assessing Unilateral Spatial Neglect: A Novel Opportunity for Data Collection

Published on: March 10, 2021

Hemispherectomy sustained before adulthood does not cause persistent hemispatial neglect.

Elisabeth B Marsh1, Melissa Newhart, Jonathan T Kleinman

  • 1Department of Neurology, The Johns Hopkins University School of Medicine, Baltimore, MD, USA.

Cortex; a Journal Devoted to the Study of the Nervous System and Behavior
|December 9, 2008
PubMed
Summary

Children and young adults undergoing hemispherectomy rarely show hemispatial neglect, suggesting the opposite hemisphere compensates for lost functions. This brain reorganization highlights the young brain's plasticity after injury.

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Area of Science:

  • Neuroscience
  • Developmental Neuroscience
  • Cognitive Neurology

Background:

  • Hemispatial neglect is common in adults post-stroke but understudied in pediatric brain injury.
  • Young brains exhibit significant plasticity, with ongoing debate about hemispheric vs. perilesional reorganization.
  • Hemispherectomy patients offer a unique model to study contralateral hemisphere functional takeover.

Purpose of the Study:

  • To determine the incidence and types of hemispatial neglect in children and young adults post-hemispherectomy.
  • To investigate which spatial attention functions the contralateral hemisphere can assume.
  • To explore the influence of age at surgery, handedness, and gender on recovery.

Main Methods:

  • Thirty-two pediatric and young adult hemispherectomy patients were assessed.
  • Two tests evaluated hemispatial neglect: a line cancellation test (egocentric neglect) and a gap detection test (allocentric neglect).
  • Statistical analysis identified neglect based on contralesional vs. ipsilesional performance.

Main Results:

  • Only one patient showed statistically significant egocentric neglect on the line cancellation test.
  • No patients exhibited significant egocentric or allocentric neglect on the gap detection test.
  • These findings suggest minimal neglect post-hemispherectomy.

Conclusions:

  • Reorganization to the contralateral hemisphere appears to occur effectively after hemispherectomy.
  • The absence of perilesional areas necessitates contralateral hemisphere takeover for spatial attention functions.
  • This study supports the remarkable adaptive capacity of the young brain following extensive unilateral cortical removal.