[Prostatic granulomas revealing a peripheral T-cell lymphoma]

Area of Science:

• Oncology
• Immunology
• Pathology

Background:

• Granulomatous inflammation is a complex pathological finding observed across diverse medical conditions.
• Diagnosing granulomatous disorders can be clinically challenging, necessitating thorough investigation.

Observation:

• A 59-year-old male presented with granulomatous prostatitis and mediastinal lymph nodes on CT scan.
• Initial diagnosis of sarcoidosis was confirmed via minor salivary gland biopsy.
• The patient later developed epidermal necrolysis, followed by a deteriorating general condition, prompting further investigation for lymphoproliferative disorders.

Findings:

• Liver and bone marrow biopsies revealed a granulomatous process.
• Autopsy confirmed anaplastic T cell lymphoma as the terminal diagnosis.
• The patient's condition worsened despite steroid therapy.

Implications:

• This case underscores the potential association between sarcoidosis and lymphoma, which can manifest as presentation, complication, or misleading association.
• The co-occurrence of anaplastic lymphoma and sarcoidosis is exceptionally rare.
• Highlights the importance of considering lymphoproliferative disorders in patients with sarcoidosis exhibiting disease progression or unusual symptoms.