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Related Concept Videos

Atherosclerosis I: Introduction01:30

Atherosclerosis I: Introduction

Atherosclerosis is a progressive disorder characterized by the buildup of plaques on the arterial inner wall, causing them to narrow and harden over time. These plaques comprise lipids, calcium, blood components, carbohydrates, and fibrous tissue. The process primarily affects the intima of large and medium-sized arteries, reducing blood flow in any artery.Etiology and risk factorsThe cause of atherosclerosis is multifactorial, involving a complex interplay among endothelial injury, lipid...
Coronary Artery Disease II: Pathophysiology01:26

Coronary Artery Disease II: Pathophysiology

Coronary Artery Disease (CAD) originates from a series of events that impair the function of coronary arteries, the blood vessels responsible for delivering oxygen-rich blood to the heart muscle. The pathophysiology of CAD is closely linked to atherosclerosis, a chronic inflammatory and lipid-driven condition affecting the vascular endothelium.1. Endothelial DamageThe process begins with damage to the vascular endothelium, which serves as a protective barrier between the blood and the vessel...
Cirrhosis II: Pathophysiology01:24

Cirrhosis II: Pathophysiology

Cirrhosis is a progressive chronic liver injury caused by prolonged inflammation, excessive fibrotic remodeling, and impaired regeneration. Over time, repeated hepatic insults disrupt the liver’s architecture and function, leading to reduced blood flow, impaired bile drainage, and diminished metabolic capacity.Pathophysiology of cirrhosisCirrhosis arises from three main responses to chronic liver damage: inflammation, immune activation, and hepatocyte death. These processes lead to structural...
Asthma-II: Pathophysiology and Classification01:26

Asthma-II: Pathophysiology and Classification

Asthma is a prevalent chronic respiratory condition marked by inflammation and hyperresponsiveness of the airways. Its pathophysiology involves complex interactions among inflammatory pathways, immune responses, and neural mechanisms.
Additionally, environmental and genetic factors play crucial roles in determining an individual's susceptibility to asthma and the severity of their condition.
Critical processes in asthma pathophysiology include:
Peripheral Artery Disease I: Introduction01:30

Peripheral Artery Disease I: Introduction

Peripheral artery disease (PAD) predominantly results from atherosclerosis, which involves the accumulation of fatty deposits, or plaques, within the walls of arteries. This causes them to narrow and harden, significantly reducing blood flow. PAD predominantly affects the legs, particularly the arteries supplying the thighs and calves. In rare cases, it may involve other arteries, including those in the arms.Etiology of PAD:The principal cause of PAD is atherosclerosis, which results from fatty...
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Asthma: Pathogenesis and Management

Asthma is a chronic pulmonary condition involving inflammation of the airways, hyper-reactivity, and reversible obstruction of the airways. This condition can significantly impact a person's quality of life, making breathing difficult and leading to distressing symptoms.
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Related Experiment Video

Updated: Jun 27, 2026

Imaging Features of Systemic Sclerosis-Associated Interstitial Lung Disease
04:44

Imaging Features of Systemic Sclerosis-Associated Interstitial Lung Disease

Published on: June 16, 2020

Scleroderma--pathophysiology.

Toshiyuki Yamamoto1

  • 1Department of Dermatology, Fukushima Medical University, Fukushima 960-1295, Japan. toyamade@fmu.ac.jp

European Journal of Dermatology : EJD
|December 9, 2008
PubMed
Summary

Scleroderma involves immune issues, vascular damage, and excess skin matrix proteins. Animal models help study this fibrotic disease

Area of Science:

  • Immunology
  • Fibrosis
  • Dermatology

Background:

  • Scleroderma is a fibrotic condition with immune abnormalities, vascular injury, and excessive extracellular matrix accumulation in the skin.
  • The exact cause of scleroderma is unknown, but it involves complex interactions between various cells and mediators.
  • Recent research suggests reactive oxygen species (ROS) and apoptosis play roles in scleroderma pathogenesis.

Purpose of the Study:

  • To review current findings on the pathophysiology of human scleroderma.
  • To describe the utility of animal models in understanding scleroderma.
  • To enhance comprehension of scleroderma pathogenesis and aid in developing new treatments.

Main Methods:

  • Review of existing literature on scleroderma pathophysiology.

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Granulocyte-dependent Autoantibody-induced Skin Blistering
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Granulocyte-dependent Autoantibody-induced Skin Blistering

Published on: October 12, 2012

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Last Updated: Jun 27, 2026

Imaging Features of Systemic Sclerosis-Associated Interstitial Lung Disease
04:44

Imaging Features of Systemic Sclerosis-Associated Interstitial Lung Disease

Published on: June 16, 2020

Granulocyte-dependent Autoantibody-induced Skin Blistering
12:23

Granulocyte-dependent Autoantibody-induced Skin Blistering

Published on: October 12, 2012

  • Analysis of findings from human studies.
  • Examination of data from various animal models of scleroderma.

    • Main Results:

    • Fibrotic condition characterized by immunological abnormalities, vascular injury, and ECM protein accumulation.
    • Complex interactions among endothelial cells, lymphocytes, macrophages, and fibroblasts mediated by cytokines, chemokines, and growth factors.
    • Involvement of reactive oxygen species (ROS) and apoptosis in scleroderma.

    Conclusions:

    • Animal models are crucial for understanding scleroderma's complex pathophysiology.
    • Further research into scleroderma pathogenesis, including ROS and apoptosis, is needed.
    • Improved understanding may lead to novel therapeutic strategies for scleroderma.