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Enhanced secretion of biologically active murine interleukin-12 by Lactococcus lactis
Antonio Fernandez1, Nikki Horn, Udo Wegmann
1BBSRC Institute of Food Research, Colney, Norwich, United Kingdom. antonio.fernandezdumont@efsa.europa.eu
Applied and Environmental Microbiology
|December 9, 2008
Abstract:
The novel signal peptide SLPmod was used for the secretion of murine interleukin-12 (mIL-12) by Lactococcus lactis. A >4-fold increase in secretion was observed when SLPmod was used instead of the Usp45-derived secretion signal. Oral delivery of this cytokine using the autoinducible host L. lactis FI5876 utilizing SLPmod resulted in a significant increase in mIL-12 plasma levels in mice.
