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A dimer-specific function of the transcription factor NFATp.

James V Falvo1, Charles H Lin, Alla V Tsytsykova

  • 1Immune Disease Institute and Harvard Medical School, 800 Huntington Avenue, Boston, MA 02115, USA.

Proceedings of the National Academy of Sciences of the United States of America
|December 9, 2008
PubMed
Summary

The transcription factor NFATp dimerizes to activate tumor necrosis factor (TNF) gene transcription. DNA binding induces NFATp dimerization, enabling interaction with coactivator CBP for gene regulation.

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