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Circadian Rhythms and Gene Regulation02:19

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The biological clock is involved in many aspects of regulating complex physiology in all animals. It was in 1935 when German zoologists, Hans Kalmus and Erwin Bünning, discovered the existence of circadian rhythm in Drosophila melanogaster. However, the internal molecular mechanisms behind the circadian clock remained a mystery until 1984, when Jeffrey C. Hall, Michael Rosbash, and Michael W. Young discovered the expression of the Per gene oscillating over a 24-hour cycle. In subsequent years,...
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Parallel Measurement of Circadian Clock Gene Expression and Hormone Secretion in Human Primary Cell Cultures
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Published on: November 11, 2016

Intermediate-term memory is modulated by the circadian clock.

Lisa C Lyons1, Charity L Green, Arnold Eskin

  • 1Department of Biology and Biochemistry, University of Houston, Houston, TX, USA. lyons@bio.fsu.edu

Journal of Biological Rhythms
|December 9, 2008
PubMed
Summary
This summary is machine-generated.

The circadian clock influences intermediate-term memory in Aplysia, affecting learning and memory processes. This study reveals that training during the subjective day enhances memory compared to nighttime training.

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Area of Science:

  • Neuroscience
  • Chronobiology
  • Behavioral Science

Background:

  • The circadian clock regulates long-term, but not short-term, memory in Aplysia.
  • Intermediate-term memory has not been previously studied in relation to the circadian clock.

Purpose of the Study:

  • To investigate the role of the circadian clock in intermediate-term memory in Aplysia.
  • To determine if circadian rhythms affect the expression of intermediate-term sensitization.

Main Methods:

  • Noxious stimulation of the tail-siphon withdrawal reflex in Aplysia using spaced training.
  • Analysis of intermediate-term sensitization dependent on MAPK signaling and protein synthesis.
  • Assessment of memory expression under light-dark cycles and constant darkness.

Main Results:

  • Intermediate-term sensitization showed strong circadian rhythms in expression.
  • Animals trained during the subjective day exhibited significantly enhanced intermediate-term memory.
  • Baseline responses were not modulated by the circadian clock.

Conclusions:

  • The circadian clock significantly modulates intermediate-term memory in Aplysia.
  • Circadian regulation extends to both intermediate-term and long-term memory processes.
  • Timing of training relative to the circadian cycle impacts memory formation.