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Updated: Jun 27, 2026
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Lung Rapid Recovery Procurement Combined with Abdominal Normothermic Regional Perfusion in Controlled Donation after Circulatory Death
Published on: August 15, 2022
Present state of nonheart-beating lung donation
David Gomez de Antonio1, Andres Varela de Ugarte
1Thoracic Surgery and Lung Transplantation Department, Hospital Universitario Puerta de Hierro, Madrid, Spain.
Current Opinion in Organ Transplantation
|December 9, 2008
Summary
Non-heart-beating donors (NHBDs) are a viable source for lung transplantation, addressing graft shortages. Research focuses on graft preservation and noninvasive predictors to ensure successful outcomes.
Area of Science:
- Cardiovascular Surgery
- Thoracic Surgery
- Transplantation Medicine
Background:
- Increasing lung transplant indications lead to graft scarcity and waiting list mortality.
- Non-heart-beating donors (NHBDs) offer a promising solution to the organ shortage.
- Lung transplantation faces challenges due to limited donor availability.
Purpose of the Study:
- To review strategies for increasing lung graft availability.
- To evaluate the potential of non-heart-beating donors (NHBDs) in lung transplantation.
- To assess advancements in graft preservation and functional prediction for NHBD lung grafts.
Main Methods:
- Review of experimental and clinical studies on NHBD lung transplantation.
- Focus on graft preservation techniques to minimize warm ischemic injury.
- Evaluation of noninvasive parameters in bronchial lavage for predicting graft function.
Main Results:
- Experimental work has improved NHBD graft preservation, reducing ischemic injury.
- Noninvasive predictors in bronchial lavage show potential for assessing graft suitability.
- Clinical use of both controlled and uncontrolled NHBDs has yielded excellent results.
Conclusions:
- Effective methods exist for protecting NHBD lung grafts from ischemic damage.
- Functional predictors will soon enable simple, noninvasive assessment of graft viability.
- NHBDs are a proven, not just promising, source for lung transplantation with positive outcomes.
