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Long Term Intravital Multiphoton Microscopy Imaging of Immune Cells in Healthy and Diseased Liver Using CXCR6.Gfp Reporter Mice
Published on: March 24, 2015
Imaging of hepatic infections
Nancy J Benedetti1, Terry S Desser, R Brooke Jeffrey
1Department of Radiology, Stanford University School of Medicine, Stanford, CA 94305-5621, USA.
Abstract:
Hepatic infections include pyogenic and amebic abscesses and fungal and parasitic diseases. Entry of the infectious organisms into the liver can occur by hematogenous spread via the portal vein or hepatic artery, ascension of the infection from the biliary tract, or from trauma. Worldwide, liver abscess is most often caused by Entamoeba histolytica, but in the developed world, pyogenic liver abscess is more common. Fungal infection is most often seen in immunosuppressed chemotherapy patients, whereas parasitic infections are seen in patients with recent travel to endemic areas of Asia, Africa, and South America. Imaging, and in particular ultrasound, plays a crucial role in following patients from treatment to resolution of disease.We review the ultrasound and computed tomographic findings and the clinical features that are characteristic of hepatic pyogenic abscess, amebic abscess, fungal infection, and parasitic infection.
Insights
This review covers hepatic infections like abscesses and parasitic diseases, detailing their causes and common locations. Imaging, especially ultrasound, is vital for diagnosing and monitoring these liver conditions.
Area of Science:
- Hepatology
- Infectious Diseases
- Radiology
Background:
- Hepatic infections encompass pyogenic and amebic abscesses, fungal, and parasitic diseases.
- Infectious agents reach the liver via hematogenous spread, biliary tract ascension, or trauma.
- Pyogenic liver abscess is more prevalent in developed nations, while amebic abscesses are globally common.
Purpose of the Study:
- To review the characteristic ultrasound and computed tomographic findings of various hepatic infections.
- To correlate imaging findings with clinical features of hepatic pyogenic abscess, amebic abscess, fungal, and parasitic infections.
Main Methods:
- Review of ultrasound and computed tomographic (CT) imaging findings.
- Analysis of clinical features associated with different hepatic infections.
- Synthesis of information on etiologies and routes of infection for hepatic pathogens.
Main Results:
- Fungal infections typically affect immunosuppressed patients.
- Parasitic infections are common in individuals with recent travel to endemic regions.
- Ultrasound and CT imaging are crucial for diagnosis and monitoring treatment response.
Conclusions:
- Understanding the distinct imaging and clinical features aids in differentiating various hepatic infections.
- Radiological modalities are essential tools for patient management and assessing treatment efficacy.
- Prompt diagnosis and appropriate imaging are key to successful outcomes in hepatic infections.
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