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Cell kinetics of gastrointestinal tumors after different nutritional regimens. A preliminary report
F Franchi1, F Rossi-Fanelli, P Seminara
1Third Institute of Clinical Medicine, Oncology Unit, University La Sapienza, Rome, Italy.
Abstract:
Forty-four cases of different untreated gastrointestinal tumors were studied with regard to cell kinetic activity. As a pilot experiment, we also determined the 3H-TdR Labeling Index (LI) in 28 patients in basal conditions and after 15 days of nutritional manipulation with prevalently lipid-based or glucose-based feeding to ascertain whether selective nutritional regimens could affect tumor proliferation. Preliminary results from this study indicate that a kinetic perturbation is induced in tumor cells by nutritional manipulation. Lipid-based feeding seems to produce effects similar to those of chemical or physical anticancer agents, thus suggesting a possible supporting role of nutritional manipulation in cancer treatment strategy.