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[IgD-lambda multiple myeloma associated with bone marrow fibrosis].

H Nakamura1, M Sakamoto, K Wakasugi

  • 1Department of Immunohematology, Hachioji Medical Center of Tokyo Medical College.

[Rinsho Ketsueki] the Japanese Journal of Clinical Hematology
|April 1, 1991
PubMed
Summary
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This case study details a rare instance of IgD multiple myeloma with significant myelofibrosis in Japan. The findings highlight the importance of further investigation into this complex hematologic syndrome.

Area of Science:

  • Hematology
  • Oncology

Background:

  • Multiple myeloma, a plasma cell malignancy, can rarely present with myelofibrosis.
  • Cases of multiple myeloma with myelofibrosis are infrequently reported, especially in Japan.

Observation:

  • A 44-year-old female presented with back pain, anemia, and leukopenia.
  • Diagnostic workup revealed IgD multiple myeloma with a markedly elevated IgD level (5420 mg/dl).
  • Bone marrow biopsy showed extensive myeloma cell infiltration and increased reticulin fibers, indicative of myelofibrosis, without features of chronic myeloproliferative disorders.

Findings:

  • The patient exhibited IgD myeloma with pronounced bone marrow fibrosis.
  • Peripheral blood smear did not show teardrop cells, and the spleen and liver were not enlarged, differentiating it from typical myelofibrosis associated with myeloproliferative neoplasms.

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Implications:

  • This case underscores the diagnostic and clinical interest in multiple myeloma associated with myelofibrosis.
  • Further research is warranted to understand the pathogenesis and clinical course of this rare syndrome.