Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Search research articles

Related Experiment Video

Updated: Jun 27, 2026

Non-Invasive Modulation and Robotic Mapping of Motor Cortex in the Developing Brain

Non-Invasive Modulation and Robotic Mapping of Motor Cortex in the Developing Brain

Published on: July 1, 2019

Computer-controlled electrical stimulation for quantitative mapping of human cortical function.

Mario F Dulay¹, Dona K Murphey, Ping Sun

¹Departments of Neurosurgery, Texas Children's Hospital, Houston Texas, USA.

Journal of Neurosurgery

|December 9, 2008

Summary

This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

A wireless subdural-contained brain-computer interface with 65,536 electrodes and 1,024 channels.

Nature electronics·2026

Same author

Size Scaling of the Electrochemical Performance of Ti<sub>3</sub>C<sub>2</sub>T<sub>x</sub> MXene Microelectrode Arrays for Electrophysiological Recording and Stimulation.

Small (Weinheim an der Bergstrasse, Germany)·2026

Same author

Microscale organization and separability of upper extremity representations in the human motor homunculus.

Research square·2026

Same author

Pituitary Apoplexy Precipitated by Non-Cranial Surgeries: An Institutional Experience.

Journal of neurological surgery. Part B, Skull base·2026

Same author

Dissociating stimulus encoding and task demands in ECoG responses from human visual cortex.

bioRxiv : the preprint server for biology·2026

Same author

Size Scaling of the Electrochemical Performance of Ti<sub>3</sub>C<sub>2</sub>T <sub><i>x</i></sub> MXene Microelectrode Arrays for Electrophysiological Recording and Stimulation.

bioRxiv : the preprint server for biology·2026

Same journal

Extent of resection as an independent predictor of survival for patients with glioblastoma as defined by the new WHO 2021 classification.

Journal of neurosurgery·2026

Same journal

Surgical treatment of schwannomas around the tarsal tunnel: a case series of 40 patients and systematic review of the literature.

Journal of neurosurgery·2026

Same journal

Direct targeting for focused ultrasound thalamotomy in the treatment of movement disorders.

Journal of neurosurgery·2026

Same journal

Development and internal validation of the Meningioma Functional Outcome Risk and Counseling Estimator 6 score, a point-based prognostic tool for predicting 6-week functional independence after intracranial meningioma resection.

Journal of neurosurgery·2026

Same journal

Connectional anatomy of the cerebellum: dentate nucleus and cerebellar peduncles from a surgical perspective.

Journal of neurosurgery·2026

Same journal

Press releases in neurosurgery: is scientific accuracy compromised in public reporting of neurosurgery research?

Journal of neurosurgery·2026

See all related articles

Computer-controlled electrical stimulation (ES) offers precise current delivery for quantitative brain mapping in neurosurgery. This method enhances data collection and the study of human cortical function, particularly in less-characterized regions.

Area of Science:

Neurosurgery
Neuroscience
Biomedical Engineering

Background:

Cortical mapping using electrical stimulation (ES) in neurosurgery often relies on manual current delivery.
This manual approach limits trial numbers and precision, leading to variable behavioral responses and hindering quantitative data collection for human cortical function studies.

Purpose of the Study:

To develop and demonstrate a computer-controlled method for precise electrical current delivery to intracranial electrodes.
To overcome limitations of manual ES for systematic and quantitative mapping of human cortical function.

Main Methods:

Developed a system for computer-controlled delivery of defined electrical current to implanted intracranial electrodes.
Implemented time-locked stimulation synchronized with behavioral tasks to systematically measure detection thresholds.

More Related Videos

Recording Human Electrocorticographic (ECoG) Signals for Neuroscientific Research and Real-time Functional Cortical Mapping

Recording Human Electrocorticographic (ECoG) Signals for Neuroscientific Research and Real-time Functional Cortical Mapping

Published on: June 26, 2012

Stimulation Location Determination using a 3D Digitizer with High-Definition Transcranial Direct Current Stimulation

Stimulation Location Determination using a 3D Digitizer with High-Definition Transcranial Direct Current Stimulation

Published on: December 20, 2019

Related Experiment Videos

Last Updated: Jun 27, 2026

Non-Invasive Modulation and Robotic Mapping of Motor Cortex in the Developing Brain

Non-Invasive Modulation and Robotic Mapping of Motor Cortex in the Developing Brain

Published on: July 1, 2019

Recording Human Electrocorticographic (ECoG) Signals for Neuroscientific Research and Real-time Functional Cortical Mapping

Recording Human Electrocorticographic (ECoG) Signals for Neuroscientific Research and Real-time Functional Cortical Mapping

Published on: June 26, 2012

Stimulation Location Determination using a 3D Digitizer with High-Definition Transcranial Direct Current Stimulation

Stimulation Location Determination using a 3D Digitizer with High-Definition Transcranial Direct Current Stimulation

Published on: December 20, 2019

Main Results:

Demonstrated the ability to rapidly and systematically measure the detection threshold for ES in the human visual cortex over numerous trials.
Validated the precision and efficiency of computer-controlled ES for quantitative mapping.

Conclusions:

Computer-controlled ES provides a robust method for systematic and quantitative study of virtually any cerebral cortex region.
This technique is particularly valuable for characterizing poorly understood cortical areas and confirming stimulation-evoked percepts.