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Cespihypotins Q-V, verticillene diterpenoids from Cespitularia hypotentaculata
Ya-Ching Shen1, Kuang-Liang Lo, Yao-Haur Kuo
1School of Pharmacy, College of Medicine, National Taiwan University, Jen-Ai Road, Sec. 1, Taipei 100, Taiwan, Republic of China. ycshen@ntu.edu.tw
Abstract:
Chemical investigation of the soft coral Cespitularia hypotentaculata resulted in the isolation of six new diterpenes, cespihypotins Q-V. The new metabolites comprised five verticillane-type diterpenes and one nor-verticillane derivative. Their structures were determined through detailed spectroscopic analyses, especially HRESIMS and 2D NMR techniques. The relative configuration was deduced by interpretation of NOESY spectra. Cespihypotin T exhibited significant cytotoxic activity against human Daoy and WiDr tumor cell lines.

