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Related Concept Videos

Skin Diseases and Disorders01:23

Skin Diseases and Disorders

Skin is the first line of defense and encounters a variety of microbes. Some pathogenic strains are often the cause of a broad range of infections of the skin and other body systems. These conditions can affect people of all ages and may have different causes, including genetic factors, infections, autoimmune reactions, environmental factors, and lifestyle choices.
Gram-positive Staphylococcus spp. and Streptococcus spp. are responsible for many of the most common skin infections. However, many...
The Skin Microbiota01:27

The Skin Microbiota

The human skin serves as a complex ecosystem inhabited by a diverse community of microorganisms, including bacteria, fungi, and viruses. This microbiome plays a critical role in maintaining skin health and defending against pathogenic invaders. The composition of microbial communities varies significantly across different regions of the body, influenced primarily by the local levels of moisture and sebum.Regional Variation in Skin MicrobiotaCutibacterium acnes predominantly colonizes sebaceous...
Acne Infection01:27

Acne Infection

Acne is a multifactorial skin condition primarily affecting adolescents and young adults, with a global prevalence estimated to exceed 75% in this demographic. The condition is characterized by the formation of comedones (blackheads and whiteheads), papules, pustules, nodules, and, in severe cases, cysts, particularly in areas rich in sebaceous glands such as the face, neck, chest, and back. The pathogenesis involves increased sebum production, follicular hyperkeratinization, colonization by...
Accessory Structures of the Skin: Sebaceous Glands01:21

Accessory Structures of the Skin: Sebaceous Glands

A sebaceous gland is a type of oil gland found almost all over the skin ( except palms and soles) and helps lubricate and waterproof the skin and hair. Most sebaceous glands are associated with hair follicles. They generate and excrete sebum, a mixture of lipids, onto the skin surface, thereby naturally lubricating the dry and dead layer of keratinized cells of the stratum corneum, keeping it pliable.
These glands that produce the oils on the skin and hair are holocrine glands. The mature...
Papillary Dermis01:11

Papillary Dermis

Dermis
The dermis might be considered the "core" of the integumentary system, as distinct from the epidermis and hypodermis. It contains blood and lymph vessels, nerves, and other structures, such as hair follicles and sweat glands. The dermis is made of two layers of connective tissue that comprise an interconnected mesh of elastin and collagenous fibers, produced by fibroblasts.
Papillary Layer
The papillary layer is made of loose, areolar connective tissue, which means the collagen and...
Reticular Dermis01:15

Reticular Dermis

The papillary and reticular dermis are the two layers of the dermis. They are made of connective tissue with fibers of collagen extending from one to the other, making the border between the two somewhat indistinct. The dermal papillae extending into the epidermis belong to the papillary layer, whereas the dense collagen fiber bundles below belong to the reticular layer.
Reticular Layer
Underlying the papillary layer is the much thicker reticular layer, composed of dense, irregular connective...

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Related Experiment Videos

Lichen planopilaris and psoriasis.

Tameka K Lane1, Hideko Kamino, Ruth F Walters

  • 1Department of Dermatology, New York University, USA.

Dermatology Online Journal
|December 9, 2008
PubMed
Summary

This case study highlights a rare instance of lichen planopilaris and psoriasis co-occurring, presenting unique diagnostic and treatment challenges for scalp alopecia.

Area of Science:

  • Dermatology
  • Pathology

Background:

  • Lichen planopilaris (LLP) is a primary cicatricial alopecia characterized by lymphocytic inflammation.
  • Psoriasis is a common inflammatory skin condition often presenting with scaly plaques.

Observation:

  • A 34-year-old woman presented with a year of itchy, scaly alopecia and violaceous papules.
  • Histopathology revealed features of both lichen planopilaris and psoriasis, including neutrophilic spongiosis.

Findings:

  • Treatment with cyclosporine and topical betamethasone valerate improved itching and redness but not scaling.
  • The case demonstrates a clinical and histopathologic overlap between LLP and psoriasiform dermatosis.

Implications:

  • This presentation suggests a potential collision of lichen planopilaris and psoriasis.

Related Experiment Videos

  • Understanding such overlaps is crucial for accurate diagnosis and effective management of complex scalp conditions.