Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Cells of the Adaptive Immune Response

Cells of the Adaptive Immune Response

The T and B lymphocytes of the adaptive immune system develop from common lymphoid progenitor cells in the bone marrow. These progenitors give rise to precursors that eventually develop into both T and B lymphocytes. As these precursors mature, they gain the ability to detect and respond to foreign antigens in the body, a process known as immunocompetence. Additionally, these precursors acquire self-tolerance, a process that ensures they do not react to self-antigens. This intricate system...

B Cell Activation and Differentiation

B Cell Activation and Differentiation

The adaptive immune response, a sophisticated defense mechanism, relies on the activation and differentiation of B lymphocytes, or B cells. These processes enable our bodies to mount a tailored response against specific pathogens such as bacteria, free virus particles, toxins, and parasites.
When naive B cells encounter a specific antigen that can bind to the B cell receptor (BCR) on their surface, they undergo sensitization to respond to the antigen's presence. Sensitization begins with...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Perineal cutaneous basal cell carcinomas in patients with familial seronegative coeliac disease: report of three cases.

The British journal of dermatology·2021

Same author

Treatment options for leishmaniasis.

Clinical and experimental dermatology·2021

Same author

Generalized pustular figurate erythema first report in two COVID-19 patients on hydroxychloroquine.

Journal of the European Academy of Dermatology and Venereology : JEADV·2020

Same author

Interdigital syphilis: a rare form of secondary syphilis.

International journal of STD & AIDS·2019

Same author

Prolonged overall survival following metastasectomy in stage IV melanoma.

Journal of the European Academy of Dermatology and Venereology : JEADV·2019

Same author

Declining recommended surgery in primary cutaneous melanoma: an analysis of risk factors and survival.

Journal of the European Academy of Dermatology and Venereology : JEADV·2019

Search research articles

Related Experiment Video

Updated: Jun 27, 2026

In Vitro Differentiation Model of Human Normal Memory B Cells to Long-lived Plasma Cells

In Vitro Differentiation Model of Human Normal Memory B Cells to Long-lived Plasma Cells

Published on: January 20, 2019

Plasma-cell-predominant B-cell pseudolymphoma.

Stephen J Nervi¹, R A Schwartz

¹Department of Dermatology, New York University, USA.

Dermatology Online Journal

|December 9, 2008

Summary

A rare case of cutaneous pseudolymphoma presented as facial masses in a woman without foreign travel history. This nonmalignant B cell proliferation highlights diagnostic challenges and potential treatment resistance in idiopathic cases.

Area of Science:

Dermatology
Pathology
Immunology

Background:

Cutaneous pseudolymphoma is a nonmalignant skin condition involving lymphocyte accumulation.
It can be triggered by various stimuli and classified based on etiology.
Diagnosis requires differentiating from cutaneous lymphomas.

Observation:

A 46-year-old woman presented with pruritic, ulcerating facial masses.
Symptoms persisted for months, with no history of foreign travel.
Clinical and histopathologic examination suggested a plasma cell-predominant B cell pseudolymphoma.

Findings:

Extensive special stains failed to identify an etiologic organism.
The presentation was consistent with idiopathic cutaneous pseudolymphoma.

More Related Videos

Establishment of Epstein-Barr Virus Growth-transformed Lymphoblastoid Cell Lines

Establishment of Epstein-Barr Virus Growth-transformed Lymphoblastoid Cell Lines

Published on: November 8, 2011

Tumor Engraftment in a Xenograft Mouse Model of Human Mantle Cell Lymphoma

Tumor Engraftment in a Xenograft Mouse Model of Human Mantle Cell Lymphoma

Published on: March 30, 2018

Related Experiment Videos

Last Updated: Jun 27, 2026

In Vitro Differentiation Model of Human Normal Memory B Cells to Long-lived Plasma Cells

In Vitro Differentiation Model of Human Normal Memory B Cells to Long-lived Plasma Cells

Published on: January 20, 2019

Establishment of Epstein-Barr Virus Growth-transformed Lymphoblastoid Cell Lines

Establishment of Epstein-Barr Virus Growth-transformed Lymphoblastoid Cell Lines

Published on: November 8, 2011

Tumor Engraftment in a Xenograft Mouse Model of Human Mantle Cell Lymphoma

Tumor Engraftment in a Xenograft Mouse Model of Human Mantle Cell Lymphoma

Published on: March 30, 2018

This condition involves benign skin lymphocyte proliferation.

Implications:

Idiopathic cutaneous pseudolymphoma can be challenging to treat.
Accurate diagnosis is crucial to avoid misclassification as lymphoma.
Further research may elucidate causative factors and improve therapeutic strategies.