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Preparing Porcine Eyes for Confocal Reflectance Microscopy to Visualize the Vitreous Collagen Fiber Network
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Perforating collagenosis.

Molly Yancovitz1, Hillary Johnson, Nadia Wang

  • 1Department of Dermatology, New York University, USA.

Dermatology Online Journal
|December 9, 2008
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Summary
This summary is machine-generated.

Acquired reactive perforating collagenosis is a rare skin condition presenting as itchy papules. It is often associated with underlying health issues like diabetes or kidney disease.

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Area of Science:

  • Dermatology
  • Pathology

Background:

  • Acquired reactive perforating collagenosis (ARPC) is a rare dermatosis.
  • It is frequently associated with pruritus and systemic conditions such as diabetes mellitus and chronic renal insufficiency.

Observation:

  • A 55-year-old male presented with a three-week history of pruritic, erythematous papules with hyperkeratotic dells on the dorsum of the left hand.
  • The eruption was preceded by swelling, redness, and itching.

Findings:

  • Histopathologic examination revealed acanthotic epidermis with a central invagination.
  • The invagination contained a plug of parakeratotic debris, collagen, and inflammatory cells, consistent with ARPC.

Implications:

  • This case highlights the clinical and histopathologic features of ARPC.
  • Effective management strategies may include topical/oral retinoids and glucocorticoids, though further research is warranted.