Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Pulmonary Tuberculosis III

Pulmonary Tuberculosis III

Tuberculosis (TB) is a contagious infection primarily affecting the lung parenchyma but which can also affect other body parts. TB can be classified based on disease development, presentation, and the affected anatomical site.
The first classification is based on the development of the disease, and it includes the following categories:

Metastasis

Metastasis

Metastasis is the spread of cancer cells from the original site to distant locations in the body. Cancer cells can spread via blood vessels (hematogenous) as well as lymph vessels in the body.
Epithelial-to-Mesenchymal Transition
The epithelial-to-mesenchymal transition or EMT is a developmental process commonly observed in wound healing, embryogenesis, and cancer metastasis. EMT is induced by transforming growth factor-beta (TGF-β) or receptor tyrosine kinase (RTK) ligands, which further...

Appendicitis

Appendicitis

Appendicitis is an acute inflammatory condition of the vermiform appendix, most commonly caused by obstruction of its lumen. The appendix is a narrow, blind-ended pouch that extends from the cecum, making it particularly prone to obstruction. Causes include fecaliths, lymphoid hyperplasia (often after viral infections), parasites, tumors, or foreign bodies. This obstruction initiates a cascade of pathological changes.Luminal Obstruction and Early InflammationAfter obstruction, normal mucosal...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Scarcity of research on breastfeeding and Ebola diseases is placing the lives of women and infants at risk: a call to specific action.

The Lancet. Global health·2025

Same author

Sex and gender differences in adverse events following influenza and COVID-19 vaccination.

Biology of sex differences·2024

Same author

Assessing a Digital Scorecard on Global Immunization Progress: Stakeholder Views and Implications for Enhancing Performance and Accountability.

Vaccines·2024

Same author

Sex and gender differences in adverse events following receipt of influenza and COVID-19 vaccination among healthcare workers.

medRxiv : the preprint server for health sciences·2024

Same author

Combining Low-Power Fractional Diode Laser With Injectable Neurotoxin and Filler: Safety of Treatment Regimen Over 6 Years.

Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.]·2021

Same author

Association between childhood negative life events with alcohol expectancies in early adolescence: Cumulative risk and latent class approaches.

Drug and alcohol dependence·2021

Search research articles

Related Experiment Video

Updated: Jun 27, 2026

Endoscopic Bilateral Nipple-sparing Mastectomy via a Single Axillary Incision with Immediate Pre-pectoral Implant-based Breast Reconstruction

Endoscopic Bilateral Nipple-sparing Mastectomy via a Single Axillary Incision with Immediate Pre-pectoral Implant-based Breast Reconstruction

Published on: May 17, 2024

Extramammary Paget disease.

Robert Anolik¹, Christine Liang, Nadia Wang

¹Department of Dermatology, New York University, USA.

Dermatology Online Journal

|December 9, 2008

Summary

This summary is machine-generated.

Extramammary Paget disease (EMPD) can present as a penile ulcer unresponsive to standard treatments. Diagnosis requires biopsy, and thorough medical evaluation is crucial due to associated cancers.

Related Experiment Videos

Last Updated: Jun 27, 2026

Endoscopic Bilateral Nipple-sparing Mastectomy via a Single Axillary Incision with Immediate Pre-pectoral Implant-based Breast Reconstruction

Endoscopic Bilateral Nipple-sparing Mastectomy via a Single Axillary Incision with Immediate Pre-pectoral Implant-based Breast Reconstruction

Published on: May 17, 2024

Area of Science:

Dermatology
Oncology
Urology

Background:

Extramammary Paget disease (EMPD) is a rare intraepithelial malignancy.
Penile presentation of EMPD is uncommon, often mimicking benign conditions.

Observation:

A 59-year-old man presented with a chronic, non-healing penile ulcer.
The ulcer was refractory to empirical treatments including topical antimicrobials, antifungals, glucocorticoids, and oral acyclovir.

Findings:

Biopsy confirmed intraepidermal neoplasm consistent with extramammary Paget disease (EMPD) via light microscopy and immunohistochemistry.
This diagnosis necessitates a comprehensive workup for associated malignancies.

Implications:

Patients with EMPD require extensive evaluation, including full-body skin exams, lymph node assessment, colonoscopy, cystoscopy, and sex-specific screenings (pelvic/breast exams for women, prostate exams/PSA for men).
Close post-treatment monitoring is essential due to the risk of recurrence and secondary malignancies.