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Related Concept Videos

Linear time-invariant Systems01:23

Linear time-invariant Systems

A system is linear if it displays the characteristics of homogeneity and additivity, together termed the superposition property. This principle is fundamental in all linear systems. Linear time-invariant (LTI) systems include systems with linear elements and constant parameters.
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Skin cancer is a type of cancer that occurs when there is an abnormal growth of skin cells, usually triggered by damage to the DNA within the skin cells. It is primarily caused by exposure to ultraviolet (UV) radiation from the sun or artificial sources like tanning beds. Skin cancer is the most common type of cancer worldwide, and its incidence continues to rise.
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Updated: Jun 27, 2026

Dermoscopy Aids in the Diagnosis of Discoid Lupus Erythematosus
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Dermoscopy Aids in the Diagnosis of Discoid Lupus Erythematosus

Published on: May 16, 2025

Linear lichen planus.

Priya Batra1, Nadia Wang, Hideko Kamino

  • 1Department of Dermatology, New York University, USA.

Dermatology Online Journal
|December 9, 2008
PubMed
Summary
This summary is machine-generated.

Linear lichen planus (LP) is a rare skin condition presenting in lines along Blaschko lines. It arises from a postzygotic mutation causing genetic changes in skin cells, leading to distinct histopathological findings.

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Published on: June 10, 2025

Area of Science:

  • Dermatology
  • Genetics

Background:

  • Linear lichen planus (LP) is an uncommon variant of lichen planus, representing less than 0.2% of cases.
  • Its characteristic linear or segmental distribution follows Blaschko lines, suggesting a genetic basis.

Observation:

  • A 50-year-old male presented with itchy, hyperpigmented papules and plaques on his right lower extremity in a linear pattern.
  • Skin biopsy confirmed findings consistent with lichen planus.

Findings:

  • Histopathology of linear LP mirrors classic LP, showing hyperkeratosis, sawtooth acanthosis, basal cell vacuolar degeneration, and a dense band-like lymphocytic infiltrate.
  • Segmental formation is hypothesized to result from postzygotic mutations leading to loss of heterozygosity in keratinocytes.

Implications:

  • Accurate clinical and histopathological differentiation of linear LP from other linear dermatoses like lichen striatus and inflammatory linear verrucous epidermal nevus is crucial for appropriate management.
  • Understanding the genetic mechanisms, such as somatic mutations, provides insight into the pathogenesis of LP variants.