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Updated: Jun 27, 2026

Chemotherapy-induced Vascular Toxicity - Real-time In vivo Imaging of Vessel Impairment

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Published on: January 7, 2015

Doxorubicin-induced hyperpigmentation.

Naheed R Abbasi¹, Nadia Wang

¹Department of Dermatology, New York University, USA.

Dermatology Online Journal

|December 9, 2008

Summary

This summary is machine-generated.

Doxorubicin, a chemotherapy drug, can cause hyperpigmentation of the skin, tongue, lips, and nails in patients with HIV and Kaposi sarcoma. This side effect often resolves after discontinuing the medication.

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Area of Science:

Oncology
Dermatology
Infectious Diseases

Background:

Human immunodeficiency virus (HIV) infection can lead to Kaposi sarcoma.
Highly active antiretroviral therapy (HAART) is a standard treatment for HIV.
Doxorubicin is a chemotherapy agent used in treating Kaposi sarcoma.

Observation:

A 39-year-old male patient with HIV and Kaposi sarcoma on HAART and doxorubicin presented with tongue hyperpigmentation.
Physical examination revealed hyperpigmented patches on the lips and longitudinal dark bands on nails.
Skin biopsy confirmed pigmentary alteration.

Findings:

Doxorubicin therapy is associated with drug-induced hyperpigmentation.
The observed hyperpigmentation affected oral mucosa and nails.
Pigmentary alterations are a known side effect of doxorubicin.

Implications:

Discontinuation of doxorubicin can lead to the resolution of hyperpigmentation.
Awareness of this side effect is crucial for clinicians managing patients on doxorubicin.
Monitoring for and managing dermatological side effects is important in cancer therapy.