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Related Concept Videos

Papillary Dermis01:11

Papillary Dermis

Dermis
The dermis might be considered the "core" of the integumentary system, as distinct from the epidermis and hypodermis. It contains blood and lymph vessels, nerves, and other structures, such as hair follicles and sweat glands. The dermis is made of two layers of connective tissue that comprise an interconnected mesh of elastin and collagenous fibers, produced by fibroblasts.
Papillary Layer
The papillary layer is made of loose, areolar connective tissue, which means the collagen and...
Skin Cancer01:30

Skin Cancer

Skin cancer is a type of cancer that occurs when there is an abnormal growth of skin cells, usually triggered by damage to the DNA within the skin cells. It is primarily caused by exposure to ultraviolet (UV) radiation from the sun or artificial sources like tanning beds. Skin cancer is the most common type of cancer worldwide, and its incidence continues to rise.
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...
Cells of the Epidermis01:24

Cells of the Epidermis

The epidermis is made of four or five layers of epithelial cells, depending on its location in the body. From deep to superficial, these layers are the stratum basale, stratum spinosum, stratum granulosum, stratum lucidum, and stratum corneum.
The cells in all these layers except the stratum basale are called keratinocytes, a type of cell that manufactures and stores the protein keratin. The keratinocytes in the stratum corneum are dead and regularly slough away, being replaced by cells from...
Acne Infection01:27

Acne Infection

Acne is a multifactorial skin condition primarily affecting adolescents and young adults, with a global prevalence estimated to exceed 75% in this demographic. The condition is characterized by the formation of comedones (blackheads and whiteheads), papules, pustules, nodules, and, in severe cases, cysts, particularly in areas rich in sebaceous glands such as the face, neck, chest, and back. The pathogenesis involves increased sebum production, follicular hyperkeratinization, colonization by...

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Related Experiment Video

Updated: Jun 27, 2026

Anterior High-Resolution Optical Coherence Tomography in the Diagnosis and Therapeutic Monitoring of Ocular Surface Squamous Neoplasia
06:15

Anterior High-Resolution Optical Coherence Tomography in the Diagnosis and Therapeutic Monitoring of Ocular Surface Squamous Neoplasia

Published on: August 9, 2024

Clear cell papulosis.

Rachel Farley-Loftus1, Nicole M Bossenbroek, Karla Rosenman

  • 1Department of Dermatology, New York University, USA.

Dermatology Online Journal
|December 9, 2008
PubMed
Summary
This summary is machine-generated.

Clear cell papulosis is a rare pediatric skin condition presenting as hypopigmented papules along milk lines. Histopathology reveals diagnostic clear cells in the epidermis, linking it to Toker cell and Paget disease origins.

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Last Updated: Jun 27, 2026

Anterior High-Resolution Optical Coherence Tomography in the Diagnosis and Therapeutic Monitoring of Ocular Surface Squamous Neoplasia
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Published on: August 9, 2024

Combining Reflectance Confocal Microscopy with Optical Coherence Tomography for Noninvasive Diagnosis of Skin Cancers via Image Acquisition
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Published on: August 18, 2022

Area of Science:

  • Dermatology
  • Pediatric Dermatology
  • Histopathology

Background:

  • Clear cell papulosis is a rare genodermatosis.
  • Its pathogenesis and relationship to other clear cell lesions remain under investigation.

Observation:

  • A 2-year-old boy presented with multiple hypopigmented, flat-topped papules on the abdomen and pubic region, following milk lines.
  • Lesions first appeared at three months and progressively increased in number.

Findings:

  • Histopathologic examination revealed large clear cells in the lower epidermis.
  • These cells stained positive with periodic acid-Schiff (PAS).
  • The findings confirmed the diagnosis of clear cell papulosis.

Implications:

  • This case highlights the characteristic presentation of clear cell papulosis in children.
  • The histopathologic findings suggest a potential link between clear cell papulosis, clear cells of Toker, and extramammary Paget disease.
  • Further research into immunohistochemical markers may elucidate the precise cellular origin and relationship between these conditions.