Parry-Romberg syndrome with coexistent morphea

Area of Science:

• Dermatology
• Neurology
• Pediatrics

Background:

• Parry-Romberg syndrome is a rare disorder characterized by progressive hemifacial atrophy.
• Morphea, a localized scleroderma, can present with skin plaques and may precede or coexist with other autoimmune conditions.
• The differential diagnosis for unilateral facial atrophy is broad, requiring careful clinical evaluation.

Observation:

• A 14-year-old female presented with a nine-year history of progressive subcutaneous atrophy affecting the right side of her face.
• The onset of facial atrophy was preceded by the development of a morpheaform plaque on the right temple.
• Clinical examination revealed significant hemiatrophy of the facial structures on the affected side.

Findings:

• The patient's presentation was consistent with a diagnosis of Parry-Romberg syndrome.
• The presence of a preceding morpheaform plaque suggests a potential link or overlap between Parry-Romberg syndrome and morphea.
• Histopathological examination of the plaque confirmed features consistent with morphea.

Implications:

• This case underscores the significant overlap between Parry-Romberg syndrome and morphea, suggesting a potential shared pathophysiology.
• Early recognition of morpheaform lesions may aid in the diagnosis of Parry-Romberg syndrome.
• Further research into the etiological factors and potential autoimmune links between these conditions is warranted.