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Case report: topical DMSO for mitomycin-C-induced skin ulceration
1Arizona Cancer Center, Tucson.
Oncology Nursing Forum
|May 1, 1991
Summary
Topical dimethylsulfoxide (DMSO) shows promise for treating severe mitomycin-C extravasations, a common complication of this chemotherapy. This approach may offer a new therapeutic option for managing these painful skin and soft tissue injuries.
Area of Science:
- Oncology
- Dermatology
- Pharmacology
Background:
- Mitomycin-C is a vital chemotherapy agent for various advanced cancers.
- Accidental extravasation of mitomycin-C can lead to severe skin and soft tissue necrosis.
- Current treatments for mitomycin-C extravasation, including heat, ice, and antidotes, have limited efficacy.
Observation:
- Two severe cases of mitomycin-C venous extravasation were treated with topical dimethylsulfoxide (DMSO).
- Standard treatments for vesicant extravasation proved ineffective in these cases.
- The topical application of DMSO was administered to the affected skin and soft tissues.
Findings:
- Both patients experienced a pronounced positive response to topical DMSO treatment.
- The severity of necrosis and ulceration appeared to be reduced by DMSO.
- Healing occurred without the need for surgical intervention in these cases.
Implications:
- Topical DMSO may represent a novel and effective antidote for mitomycin-C extravasation.
- This treatment could potentially mitigate the need for extensive surgical procedures.
- Further clinical studies are warranted to validate the efficacy and safety of DMSO for chemotherapy extravasations.