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Updated: Jun 27, 2026

Interventional Diagnostic Procedure: A Practical Guide for the Assessment of Coronary Vascular Function
Published on: March 15, 2022
Clopidogrel use and bleeding after coronary artery bypass graft surgery
John Hyung-Jun Kim1, L Kristin Newby, Robert M Clare
1Department of Medicine, Stanford University Medical Center, Palo Alto, CA, USA.
Background:
Short-term use of clopidogrel plus aspirin among patients with acute coronary syndrome reduces ischemic events, but concerns about coronary artery bypass graft (CABG) surgery-related bleeding limit its early use.
Methods:
Using data from 4,794 consecutive CABG procedures in the Duke Databank for Cardiovascular Disease (January 1999 to December 2003), we developed multivariable models for associations with CABG-related bleeding defined as reoperation for bleeding, red cell transfusion, and a composite of reoperation/transfusion/hematocrit drop>or=15%. We examined clopidogrel use
Results:
Of 4,794 CABG patients, 332 (6.9%) received clopidogrel
Conclusion:
Clopidogrel administration
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