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Updated: Jun 27, 2026
07:29
Cell-free Biochemical Fluorometric Enzymatic Assay for High-throughput Measurement of Lipid Peroxidation in High Density Lipoprotein
Published on: October 12, 2017
Oxidized phospholipids: biomarker for cardiovascular diseases
Mohammad Z Ashraf1, Niladri S Kar, Eugene A Podrez
1Department of Molecular Cardiology, Cleveland Clinic, Lerner Research Institute, ND50, 9500 Euclid Ave., Cleveland, OH 44195, USA. ashrafz@ccf.org
The International Journal of Biochemistry & Cell Biology
|December 9, 2008
Summary
Oxidized phospholipids trigger inflammation and atherosclerosis. Understanding their pathways and signaling is key to developing treatments for these diseases and related conditions.
Area of Science:
- Biochemistry
- Immunology
- Cardiovascular Science
Background:
- Oxidized phospholipids (OxPLs) are key mediators of inflammation.
- OxPLs initiate and regulate cellular events contributing to atherosclerosis.
- These molecules interact with cellular receptors, generating inflammatory signals.
Purpose of the Study:
- To elucidate the role of oxidized phospholipids in inflammation and atherosclerosis.
- To understand the biosynthetic pathways and receptor interactions of OxPLs.
- To explore the potential of OxPLs as biomarkers for atherosclerosis and thrombosis.
Main Methods:
- Review of existing literature on oxidized phospholipid metabolism and function.
- Analysis of cellular signaling pathways activated by OxPLs.
- Evaluation of evidence for OxPLs as in vivo biomarkers.
Main Results:
- Oxidized phospholipids are produced through enzymatic and non-enzymatic pathways.
- OxPLs accumulate in vivo and are implicated in atherosclerosis and thrombosis.
- Specific receptors mediate the cellular responses to OxPLs.
Conclusions:
- Oxidized phospholipids are critical initiators and modulators of inflammatory processes.
- Understanding OxPL biosynthesis, receptor specificity, and signaling is vital for atherosclerosis and thrombosis research.
- Oxidized phospholipids show promise as biomarkers for assessing disease extent.
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