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Updated: Jun 27, 2026

Human Ovarian Surface Epithelium Organoids as a Platform to Study Tissue Regeneration
Published on: August 16, 2024
Virilization persists in a woman with an androgen-secreting granulosa cell tumor
Satin S Patel1, Kelley S Carrick, Bruce R Carr
1Departments of Obstetrics & Gynecology, University of Texas Southwestern Medical Center, Dallas, Texas 75390-9032, USA.
Objective:
To report a case of a woman who presented with amenorrhea and masculinization secondary to an androgen-secreting granulosa cell (GC) tumor, with refractory masculinization.
Design:
Case report.
Setting:
University medical center.
Patient(S):
A 45-year-old woman with abrupt onset of virilization with high serum androgen levels.
Intervention(S):
Exploratory laparotomy with full staging.
Main Outcome Measure(S):
Surgical findings and histopathologic observations are included in this report.
Result(S):
Pathologic examination revealed an inhibin stain positive GC tumor of the adult type. Virilization has persisted for 8 years after surgery.
Conclusion(S):
Adult-type GC tumor is an extremely rare cause of virilization. Masculinization features may persist in the absence of high androgen levels.
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