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Malaria pathogenesis in humans reflects a delicate interplay between parasite biology and host response. Clinical illness reflects a host’s immune response to the parasite’s asexual replication cycle, which is often asymptomatic in individuals with partial immunity. From the parasite's perspective, transmission between mosquito and human with minimal host pathology is evolutionarily advantageous. Among the six Plasmodium species infecting humans, P. falciparum and P. vivax dominate in global...

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Standard Membrane Feeding Assay for the Detection of Plasmodium falciparum Infection in Anopheles Mosquito Vectors

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Published on: May 12, 2022

Can malaria be eliminated?

Brian Greenwood¹

¹Department of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, London, UK. brian.greenwood@lshtm.ac.uk

Transactions of the Royal Society of Tropical Medicine and Hygiene

|December 9, 2008

Summary

This summary is machine-generated.

Malaria eradication is not feasible with current tools, but malaria elimination is a realistic goal for many countries. This shift in strategy is debated but offers a viable path forward for malaria control.

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Area of Science:

Global Health
Infectious Disease Control
Malariology

Background:

The goal of malaria eradication was abandoned in 1969.
In 2007, malaria eradication was revived by the Bill and Melinda Gates Foundation, gaining endorsement from the WHO and Roll Back Malaria Partnership.

Observation:

The revival of malaria eradication has sparked significant debate among researchers and control program managers.
A consensus suggests that while theoretically possible, malaria eradication is unlikely in the medium term with existing interventions.

Findings:

Malaria elimination, defined as the cessation of local transmission, is considered a feasible short- to medium-term objective.
An increasing number of countries are achieving success in controlling malaria, making elimination a tangible goal.

Implications:

The focus may need to shift from global eradication to regional and national elimination strategies.
Further research and development of novel control tools may be necessary to achieve eventual eradication.
Successful malaria elimination in endemic countries can serve as a model for others.