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Updated: Jun 27, 2026

Multiplex Therapeutic Drug Monitoring by Isotope-dilution HPLC-MS/MS of Antibiotics in Critical Illnesses

Multiplex Therapeutic Drug Monitoring by Isotope-dilution HPLC-MS/MS of Antibiotics in Critical Illnesses

Published on: August 30, 2018

Antibiotic use: is appropriateness expensive?

V von Gunten¹, J-P Reymond, K Boubaker

¹Department of Pharmacy, Central Institute of the Valais Hospitals, Sion, Switzerland.

The Journal of Hospital Infection

|December 9, 2008

Summary

This summary is machine-generated.

Antibiotic misuse is common, with 37% of prescriptions unnecessary and 45% of indicated therapies inadequate. Unnecessary antibiotic use was cheaper, often due to oral administration, unlike indicated treatments.

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Published on: July 24, 2021

Area of Science:

Medical Research
Pharmacology
Infectious Diseases

Background:

Antibiotic misuse represents a significant global health challenge.
Inappropriate antibiotic prescriptions contribute to antimicrobial resistance and increased healthcare costs.

Purpose of the Study:

To evaluate the appropriateness and adequacy of antibiotic prescriptions in a hospital setting.
To analyze the cost-effectiveness of indicated versus unjustified antibiotic therapies.

Main Methods:

Retrospective analysis of 600 antibiotic prescriptions across three hospitals.
Multivariate analysis to identify factors influencing prescription appropriateness and cost.

Main Results:

37% of all antibiotic prescriptions were deemed unnecessary.
45% of indicated antibiotic therapies were considered inadequate.
Unjustified antibiotic treatments were less expensive than indicated ones, often due to oral administration.

Conclusions:

Significant rates of antibiotic misuse and inadequate therapy exist.
Optimizing antibiotic prescribing is crucial for improving patient outcomes and controlling costs.