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Related Concept Videos

Antiepileptic Drugs: Potassium Channel Activators01:20

Antiepileptic Drugs: Potassium Channel Activators

Ezocgabine or retigabine, an antiepileptic drug of remarkable efficacy, has revolutionized the management of seizures. It is a potassium channel activator, explicitly targeting the family of Q subtype potassium channels. It enhances the transmembrane potassium currents, regulating neuronal excitability. This action stabilizes the resting membrane potential, a pivotal factor in mitigating the hyperexcitability that characterizes epilepsy.
Ezogabine has gained approval as an adjunctive treatment...
Antiepileptic Drugs: Modulators of Neurotransmitter Release Mediated by SV2A Protein01:20

Antiepileptic Drugs: Modulators of Neurotransmitter Release Mediated by SV2A Protein

Antiepileptic drugs, such as levetiracetam (Keppra) and brivaracetam (Briviact), have emerged as crucial tools in managing epilepsy. These medications exert their therapeutic effects by targeting the synaptic vesicle protein SV2A, a transmembrane glycoprotein primarily found in the brain.
SV2A is a transmembrane glycoprotein located predominantly in the brain, modulating the release of neurotransmitters for neuronal communication. Both levetiracetam and brivaracetam exhibit a high affinity for...
Antiepileptic Drugs: GABAergic Pathway Potentiators01:18

Antiepileptic Drugs: GABAergic Pathway Potentiators

γ-aminobutyric acid or GABA, plays a pivotal role as an inhibitory neurotransmitter in the brain. GABA pathway potentiators, also known as GABAergic drugs, are a class of pharmaceutical agents designed to enhance the functioning of the GABAergic system. These medications primarily treat epilepsy, a neurological disorder characterized by recurrent seizures.
The key GABA pathway potentiators used in epilepsy management are as follows.
Benzodiazepines are a well-known class of drugs used for their...
Antiepileptic Drugs: Glutamate Antagonists01:14

Antiepileptic Drugs: Glutamate Antagonists

Glutamate is a fundamental neurotransmitter in the central nervous system, playing a vital role in neuronal communication and various cognitive processes. Glutamate stands as the principal excitatory neurotransmitter in the brain. Its presence is crucial for the communication between neurons, underpinning essential processes such as synaptic transmission, neuronal excitability, and plasticity. These functions are vital for higher-order cognitive processes, including learning and memory. The...
Antiepileptic Drugs: Calcium Channel Blockers01:17

Antiepileptic Drugs: Calcium Channel Blockers

Calcium channel blockers, a class of antiepileptic drugs, regulate the flow of calcium ions within neurons.
Calcium channel blockers exert their antiepileptic effects by targeting T-type calcium channels, which are integral to transmitting nerve signals in the central nervous system. These channels allow the passage of calcium ions, which are vital for neuronal communication. By inhibiting T-type calcium channels, calcium channel blockers effectively reduce the release of neurotransmitters and...
Antiepileptic Drugs: Sodium Channel Blockers01:08

Antiepileptic Drugs: Sodium Channel Blockers

Antiepileptic drugs are specialized medications that prevent seizures in individuals diagnosed with epilepsy. These drugs primarily function by blocking the movement of sodium ions through channels in the neuronal membrane, inhibiting the repetitive firing of action potentials often associated with seizures.
Sodium channel blockers modulate ion channels, particularly voltage-gated sodium channels. They block only sodium ion movement.
Among the most commonly prescribed antiepileptic drugs are...

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Updated: Jun 27, 2026

Electrophoretic Delivery of γ-aminobutyric Acid (GABA) into Epileptic Focus Prevents Seizures in Mice
07:01

Electrophoretic Delivery of γ-aminobutyric Acid (GABA) into Epileptic Focus Prevents Seizures in Mice

Published on: May 16, 2019

Eslicarbazepine acetate.

Paul L McCormack1, Dean M Robinson

  • 1Wolters Kluwer Health Adis, Auckland, New Zealand. demail@adis.co.nz

CNS Drugs
|December 10, 2008
PubMed
Summary
This summary is machine-generated.

Eslicarbazepine acetate effectively reduces seizure frequency in adults with partial-onset seizures. This novel treatment also improves quality of life and reduces depressive symptoms, demonstrating good tolerability.

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Lipidomics and Transcriptomics in Neurological Diseases
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Last Updated: Jun 27, 2026

Electrophoretic Delivery of γ-aminobutyric Acid (GABA) into Epileptic Focus Prevents Seizures in Mice
07:01

Electrophoretic Delivery of γ-aminobutyric Acid (GABA) into Epileptic Focus Prevents Seizures in Mice

Published on: May 16, 2019

Lipidomics and Transcriptomics in Neurological Diseases
09:58

Lipidomics and Transcriptomics in Neurological Diseases

Published on: March 18, 2022

Area of Science:

  • Neuroscience
  • Pharmacology
  • Clinical Neurology

Background:

  • Eslicarbazepine acetate (ESL) is a novel prodrug of eslicarbazepine (S-licarbazepine).
  • It functions as a voltage-gated sodium channel antagonist.
  • ESL is under investigation for adjunctive treatment in adults with treatment-refractory partial-onset seizures.

Purpose of the Study:

  • To evaluate the efficacy and safety of ESL as an adjunctive therapy for partial-onset seizures.
  • To assess the impact of ESL on seizure frequency, quality of life, and depressive symptoms.
  • To determine the long-term effects and tolerability of ESL treatment.

Main Methods:

  • Phase III clinical trials were conducted to assess ESL efficacy and safety.
  • Patients received once-daily doses of ESL (800 mg or 1200 mg) or placebo.
  • Long-term, open-label treatment and quality-of-life assessments (QOLIE-31, MADRS) were performed.

Main Results:

  • ESL (800 and 1200 mg) significantly reduced seizure frequency compared to placebo over 12 weeks.
  • Sustained seizure frequency reductions were observed during up to 1 year of open-label treatment.
  • Significant improvements in health-related quality of life and reductions in depressive symptoms were noted.

Conclusions:

  • Eslicarbazepine acetate demonstrates significant efficacy in reducing seizure frequency in adults with partial-onset seizures.
  • Long-term treatment with ESL leads to sustained seizure control and improves quality of life.
  • ESL is generally well-tolerated, with most adverse events being mild to moderate and transient.