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[Immunohistochemical localization of transforming growth factor-beta (TGF-beta) in smooth muscle tissue]
P Colosetti1, R M Parache, C Rivat
1Unité no. 284, I.N.S.E.R.M., Vandoeuvre-lès-Nancy.
Abstract:
Anti-TGF-beta antibodies were raised in rabbits against a C-terminal synthetic peptide whose amino acid sequence was chosen after human TGF-beta 1 primary sequence antigenic study by continuous epitope prediction. Immunopurified antibodies were used for an immunohistochemical localization in normal and pathological human tissues. Smooth muscular type tissue seems to be an elective target.