Gastrointestinal eosinophil-mediated disorders and their treatment

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Three-Dimensional Cell Culture Models to Investigate the Epithelial Barrier in Eosinophilic Esophagitis
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Amal Assa'ad1

  • 1Division of Allergy and Immunology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229, USA. amal.assa'ad@cchmc.org

Current Allergy and Asthma Reports
|December 10, 2008
PubMed

Insights

Eosinophilic esophagitis is increasingly recognized in children presenting with gastrointestinal issues. Recent research covers its incidence, diagnosis, complications, and genetic factors.

Area of Science:

  • Pediatric Allergy and Immunology
  • Gastroenterology

Background:

  • Eosinophilic esophagitis (EoE) is a growing concern in pediatric care.
  • Patients present with symptoms like vomiting, feeding difficulties, abdominal pain, dysphagia, and food impaction.

Purpose of the Study:

  • To review recent research on eosinophilic esophagitis in pediatric patients.
  • To highlight key findings in incidence, diagnosis, natural history, and treatment.

Main Methods:

  • Literature review of published research over the past 3 years.
  • Focus on studies addressing incidence, patient populations, diagnostics, natural history, complications, therapies, and pathogenesis.

Main Results:

  • Research has expanded understanding of EoE incidence in various populations.
  • New insights into diagnostic features, natural history, and complications have emerged.
  • Topical steroid therapies and genetic markers are areas of active investigation.

Conclusions:

  • Eosinophilic esophagitis is a significant diagnosis for pediatric allergists and immunologists.
  • Continued research is crucial for improving diagnosis and management of EoE.

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