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Related Experiment Video

Updated: Jun 27, 2026

Benefits of Cardiac Resynchronization Therapy in an Asynchronous Heart Failure Model Induced by Left Bundle Branch Ablation and Rapid Pacing

Benefits of Cardiac Resynchronization Therapy in an Asynchronous Heart Failure Model Induced by Left Bundle Branch Ablation and Rapid Pacing

Published on: December 11, 2017

Dual-site left ventricular cardiac resynchronization therapy.

Luigi Padeletti¹, Andrea Colella, Antonio Michelucci

¹University of Florence, Florence, Italy. lpadeletti@interfree.it

The American Journal of Cardiology

|December 10, 2008

Summary

Dual-site left ventricular (LV) cardiac resynchronization therapy (CRT) did not improve acute hemodynamic response over optimal single-site LV CRT. Optimizing the LV pacing site and atrioventricular interval is key for effective CRT.

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Last Updated: Jun 27, 2026

Benefits of Cardiac Resynchronization Therapy in an Asynchronous Heart Failure Model Induced by Left Bundle Branch Ablation and Rapid Pacing

Benefits of Cardiac Resynchronization Therapy in an Asynchronous Heart Failure Model Induced by Left Bundle Branch Ablation and Rapid Pacing

Published on: December 11, 2017

Real-Time Cardiac Mapping with a Noninvasive Imageless Electrocardiographic Imaging System

Real-Time Cardiac Mapping with a Noninvasive Imageless Electrocardiographic Imaging System

Published on: April 11, 2025

Area of Science:

Cardiology
Biomedical Engineering
Electrophysiology

Background:

Cardiac resynchronization therapy (CRT) aims to improve heart function in heart failure patients.
Simultaneous stimulation of two left ventricular (LV) sites is explored to enhance CRT effectiveness.
Assessing acute hemodynamic response is crucial for optimizing CRT strategies.

Purpose of the Study:

To evaluate the acute hemodynamic response to dual-site LV CRT.
To compare dual-site LV CRT with single-site LV CRT in heart failure patients.
To determine if adding a second LV lead improves hemodynamic outcomes.

Main Methods:

12 CRT candidates (NYHA classes III-IV, QRS ≥120 ms) underwent dual LV lead implantation.
Pressure-volume measurements using a conductance catheter assessed LV function.
CRT configurations included single-site (site A or B) and dual-site LV pacing at varied atrioventricular intervals.

Main Results:

Single-site LV CRT at the posterolateral vein (site A) significantly improved stroke volume and LV synchrony.
Dual-site LV CRT showed modest improvements over single-site CRT at intermediate atrioventricular intervals.
Optimized single-site LV CRT yielded similar hemodynamic results to dual-site LV CRT.

Conclusions:

Adding a second LV lead does not further enhance acute hemodynamic response compared to optimal single-site CRT.
Optimal selection of the LV pacing site and atrioventricular interval is critical for CRT efficacy.
Further research may explore long-term benefits and patient selection for dual-site LV CRT.