Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Mitral Stenosis I: Introduction01:22

Mitral Stenosis I: Introduction

Mitral Valve Stenosis (MVS) is a heart condition where the mitral valve narrows, impeding blood circulation from the left atrium to the left ventricle. The etiology and pathophysiology of this condition are multifaceted, leading to a cascade of cardiovascular complications.Causes of Mitral Valve StenosisRheumatic Heart Disease: It is the main cause of mitral valve stenosis, particularly in developing nations. This condition arises from rheumatic fever, an inflammatory illness resulting from...
Heart Failure II: Pathophysiology01:29

Heart Failure II: Pathophysiology

Systolic Heart Failure and Compensatory MechanismsSystolic heart failure (also termed HFrEF, Heart Failure with Reduced Ejection Fraction) is the most prevalent type of heart filure. It results in a decreased volume of blood being pumped from the ventricle. The aortic arch and carotid sinuses have baroreceptors that detect reduced blood pressure, triggering the sympathetic nervous system (SNS) to release epinephrine and norepinephrine. Initially, this response aims to boost heart rate and...
Mitral Regurgitation I: Introduction01:20

Mitral Regurgitation I: Introduction

Mitral regurgitation is characterized by the backward circulation of blood from the left ventricle to the left atrium during systole, a phase of the cardiac cycle when the heart contracts and pumps blood out of the chambers. This abnormal flow occurs primarily due to the dysfunction of the mitral valve or its supporting structures, which include the mitral leaflets, chordae tendineae, annulus, and papillary muscles.Etiology and Mechanisms:Primary Mitral Regurgitation: This type arises from...
Aortic Regurgitation II: Clinical Features and Diagnostic Tests01:22

Aortic Regurgitation II: Clinical Features and Diagnostic Tests

Aortic valve regurgitation (AR) occurs when the aortic valve fails to close properly, allowing blood to flow backward from the aorta into the left ventricle. This backflow can result in two distinct clinical presentations: acute and chronic AR, each characterized by its own set of symptoms and physical findings.Acute Aortic RegurgitationAcute AR presents with a sudden onset of severe symptoms. Patients typically experience profound dyspnea (shortness of breath), chest pain, and signs of left...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Helping Our Patients With Valvular Heart Disease: A Call to Action.

Journal of the American College of Cardiology·2026
Same author

Adult Congenital Heart Disease Workforce Challenges in the United States: Current State and Future Needs: Proceedings from the American College of Cardiology (ACC), Adult Congenital Pediatric Cardiology (ACPC) Council Adult Congenital Heart Disease Summit.

JACC. Advances·2026
Same author

What Has Changed Since the First ACC/AHA Guidelines for the Management of Adult Congenital Heart Disease in 2008?

Journal of the American College of Cardiology·2026
Same author

Mortality and Morbidity Following Heart Failure Hospitalization in Adults With and Without Congenital Heart Disease.

Mayo Clinic proceedings·2026
Same author

Prevalence, aetiology, and outcomes of native pulmonary regurgitation in the general adult population.

European heart journal. Cardiovascular Imaging·2025
Same author

Normal Cardiac Anatomy and Clinical Evaluation.

Advances in experimental medicine and biology·2024

Related Experiment Video

Updated: Jun 27, 2026

Echocardiographic Assessment of Cardiac Anatomy and Function in Adult Rats
08:09

Echocardiographic Assessment of Cardiac Anatomy and Function in Adult Rats

Published on: December 13, 2019

Effect of operation for Ebstein anomaly on left ventricular function.

Morgan L Brown1, Joseph A Dearani, Gordon K Danielson

  • 1Division of Cardiovascular Surgery, Mayo Clinic Center for Congenital Heart Defects, Mayo Clinic College of Medicine, Mayo Clinic and Foundation, Rochester, Minnesota, USA.

The American Journal of Cardiology
|December 10, 2008
PubMed
Summary
This summary is machine-generated.

Left ventricular (LV) dysfunction in Ebstein anomaly patients undergoing surgery is uncommon but increases early mortality. However, LV function improves post-operation, with favorable long-term survival, indicating prompt tricuspid valve repair is beneficial.

More Related Videos

Morphological and Functional Assessment of the Right Ventricle Using 3D Echocardiography
07:11

Morphological and Functional Assessment of the Right Ventricle Using 3D Echocardiography

Published on: October 28, 2020

Evaluation of Left Ventricular Structure and Function using 3D Echocardiography
06:34

Evaluation of Left Ventricular Structure and Function using 3D Echocardiography

Published on: October 28, 2020

Related Experiment Videos

Last Updated: Jun 27, 2026

Echocardiographic Assessment of Cardiac Anatomy and Function in Adult Rats
08:09

Echocardiographic Assessment of Cardiac Anatomy and Function in Adult Rats

Published on: December 13, 2019

Morphological and Functional Assessment of the Right Ventricle Using 3D Echocardiography
07:11

Morphological and Functional Assessment of the Right Ventricle Using 3D Echocardiography

Published on: October 28, 2020

Evaluation of Left Ventricular Structure and Function using 3D Echocardiography
06:34

Evaluation of Left Ventricular Structure and Function using 3D Echocardiography

Published on: October 28, 2020

Area of Science:

  • Cardiology
  • Cardiac Surgery
  • Congenital Heart Disease

Background:

  • Ebstein anomaly is a rare congenital heart defect.
  • Left ventricular (LV) systolic dysfunction can occur in Ebstein anomaly patients.
  • The impact of LV dysfunction on surgical outcomes for Ebstein anomaly is not well-defined.

Purpose of the Study:

  • To evaluate the outcomes of patients with Ebstein anomaly and left ventricular dysfunction who underwent surgical repair.
  • To identify risk factors for mortality in this patient population.

Main Methods:

  • Retrospective review of 539 Ebstein anomaly patients operated between 1972 and 2006.
  • Preoperative LV function assessed by echocardiography.
  • Analysis of early and late mortality, functional status, and survival rates.

Main Results:

  • 50 out of 495 patients (10.1%) had moderate or severe LV systolic dysfunction.
  • Early mortality in the LV dysfunction group was 10%.
  • LV function improved post-operatively in most patients; 1-, 5-, and 10-year survival rates were 86%, 77%, and 67% respectively.
  • LV dysfunction was an independent predictor of late mortality (HR 3.76, p <0.001).

Conclusions:

  • LV systolic dysfunction is an infrequent but significant risk factor for increased late mortality in Ebstein anomaly.
  • Despite higher early mortality, surgical intervention leads to favorable late outcomes and improved LV function.
  • Prompt tricuspid valve repair is recommended for patients with decreasing LV function, rather than a contraindication for surgery.