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Published on: October 17, 2025
Development and perspective of current Brazilian studies on the epidemiology of childhood leukemia
Maria S Pombo de Oliveira1, Sergio Koifman, Gisele M Vasconcelos
1Hematology-Oncology Pediatric Program, Research Center, Instituto Nacional de Câncer, Rio de Janeiro, Brazil. mpombo@inca.gov.br
Abstract:
In this concise report, we describe the history and evolution of childhood acute leukemia studies in Brazil, and the application if key biomarkers for clinical trials and epidemiological studies over the past 8 years. Highlights of each ongoing study are summarized. A Brazilian network integrating hospitals and scientific institutions from all country regions has been established. This organization is made possible through informatics and computer networking, and the standardization of pathological reviews including immunophenotyping and molecular characterization of childhood leukemias. The unique characteristics of the Brazilian population combined with a large clinical and epidemiologic framework for patient ascertainment has enabled large-scale epidemiological studies on childhood leukemia in Brazil.
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