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HPL-2/HP1 prevents inappropriate vulval induction in Caenorhabditis elegans by acting in both HYP7 and vulval
Sonia Schott1, Fabien Ramos, Vincent Coustham
1Ecole Normale Superieure de Lyon, Laboratory of Molecular and Cellular Biology, UMR5239, 69007 Lyon, France.
Genetics
|December 10, 2008
Abstract:
A current model for Caenorhabditis elegans vulval cell fate specification is that SynMuv genes act redundantly in the hyp7 hypodermal syncytium to repress the LIN-3/EGF inducer and prevent ectopic vulval induction of vulva precursor cells (VPCs). Here we show that the SynMuv gene hpl-2/HP1 has an additional function in VPCs, where it may act through target genes including LIN-39/Hox.
