Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Modeling in Therapy01:26

Modeling in Therapy

Modeling, a key technique in therapy, uses observational learning to help clients acquire and practice new skills by watching therapists demonstrate desired behaviors. This approach, rooted in Albert Bandura's concept of vicarious learning, plays a significant role in therapeutic interventions for various psychological conditions, including social anxiety, ADHD, and depression.
Participant Modeling
Participant modeling involves therapists demonstrating calm and effective behaviors in situations...
Pharmacokinetic Models: Comparison and Selection Criterion01:26

Pharmacokinetic Models: Comparison and Selection Criterion

Physiological and compartmental models are valuable tools used in studying biological systems. These models rely on differential equations to maintain mass balance within the system, ensuring an accurate representation of the dynamic processes at play.
Physiological models take a detailed approach by considering specific molecular processes. They can predict drug distribution, metabolism, and elimination changes, providing a comprehensive understanding of how drugs interact with the body.
Models of Health Promotion and Illness Prevention I01:25

Models of Health Promotion and Illness Prevention I

A model is a theoretical way to understand a concept or an idea. Models can overcome barriers to health regardless of diverse economic and cultural backgrounds. In addition, models make the task easier by providing different ways to approach complex issues. There are two major health promotion models: the health belief model and the health promotion model.
The health belief model (HBM) attempts to predict health-related behavior in specific belief patterns. According to the HBM, a person's...
Mechanistic Models: Compartment Models in Individual and Population Analysis01:23

Mechanistic Models: Compartment Models in Individual and Population Analysis

Mechanistic models are utilized in individual analysis using single-source data, but imperfections arise due to data collection errors, preventing perfect prediction of observed data. The mathematical equation involves known values (Xi), observed concentrations (Ci), measurement errors (εi), model parameters (ϕj), and the related function (ƒi) for i number of values. Different least-squares metrics quantify differences between predicted and observed values. The ordinary least squares (OLS)...
Mechanistic Models: Overview of Compartment Models01:21

Mechanistic Models: Overview of Compartment Models

Mechanistic models, a category encompassing both physiological and compartmental modeling, differ from empirical models' approaches to incorporating known factors about the systems being modeled. Empirical models describe data with minimal assumptions, while mechanistic models aim to provide a robust description of available data by specifying assumptions and integrating known factors about the system. Compartmental analysis is a key example of a mechanistic model in pharmacokinetics and...
Naturalistic Observations02:30

Naturalistic Observations

If you want to understand how behavior occurs, one of the best ways to gain information is to simply observe the behavior in its natural context. However, people might change their behavior in unexpected ways if they know they are being observed. How do researchers obtain accurate information when people tend to hide their natural behavior? As an example, imagine that your professor asks everyone in your class to raise their hand if they always wash their hands after using the restroom. Chances...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

A prospective, observational program evaluation of hyperbaric oxygen therapy for veterans with posttraumatic stress disorder.

Psychological trauma : theory, research, practice and policy·2026
Same author

Apolipoprotein A1 Enhances Endothelial Cell Survival in an <i>In Vitro</i> Model of ALS.

eNeuro·2022
Same author

Cell-Free Extracellular Vesicles Derived from Human Bone Marrow Endothelial Progenitor Cells as Potential Therapeutics for Microvascular Endothelium Restoration in ALS.

Neuromolecular medicine·2020
Same author

Fighting the War Against COVID-19 via Cell-Based Regenerative Medicine: Lessons Learned from 1918 Spanish Flu and Other Previous Pandemics.

Stem cell reviews and reports·2020
Same author

Treatment with shCCL20-CCR6 nanodendriplexes and human mesenchymal stem cell therapy improves pathology in mice with repeated traumatic brain injury.

Nanomedicine : nanotechnology, biology, and medicine·2020
Same author

Advancing Stem Cell Therapy for Repair of Damaged Lung Microvasculature in Amyotrophic Lateral Sclerosis.

Cell transplantation·2020

Related Experiment Video

Updated: Jun 27, 2026

Characterization of Complex Systems Using the Design of Experiments Approach: Transient Protein Expression in Tobacco as a Case Study
20:24

Characterization of Complex Systems Using the Design of Experiments Approach: Transient Protein Expression in Tobacco as a Case Study

Published on: January 31, 2014

Experimental models: help or hindrance.

Alison E Willing1

  • 1Center of Excellence for Aging and Brain Repair, University of South Florida, MDC 78, 12901 Bruce B. Downs Boulevard, Tampa, FL 33612, USA. awilling@health.usf.edu

Stroke
|December 10, 2008
PubMed
Summary
This summary is machine-generated.

Rodent models show promise for stroke cell therapies, but translation to human trials requires better study designs. Following guidelines can improve clinical relevance and therapeutic development.

More Related Videos

Signal Attenuation as a Rat Model of Obsessive Compulsive Disorder
09:29

Signal Attenuation as a Rat Model of Obsessive Compulsive Disorder

Published on: January 9, 2015

Related Experiment Videos

Last Updated: Jun 27, 2026

Characterization of Complex Systems Using the Design of Experiments Approach: Transient Protein Expression in Tobacco as a Case Study
20:24

Characterization of Complex Systems Using the Design of Experiments Approach: Transient Protein Expression in Tobacco as a Case Study

Published on: January 31, 2014

Signal Attenuation as a Rat Model of Obsessive Compulsive Disorder
09:29

Signal Attenuation as a Rat Model of Obsessive Compulsive Disorder

Published on: January 9, 2015

Area of Science:

  • Neuroscience
  • Regenerative Medicine
  • Translational Research

Background:

  • Many experimental stroke therapeutics show efficacy in animal models but fail in human clinical trials.
  • Cellular therapies offer potential for stroke recovery, yet clinical translation remains a significant challenge.

Purpose of the Study:

  • To review the utility, advantages, and disadvantages of current rodent models for stroke cell therapy development.
  • To assess how these models have been applied in preclinical research for stroke.

Main Methods:

  • Review of existing literature on rodent models for experimental stroke.
  • Analysis of the application and limitations of these models in cellular therapy research.
  • Examination of recommendations from the Stroke Academic Industry Roundtable.

Main Results:

  • Rodent models are valuable tools, but their utility is limited by methodological inconsistencies.
  • The lack of clinical translation is not due to inherent flaws in animal models but rather in study design and trial execution.
  • Adherence to established guidelines can enhance the clinical relevance of preclinical stroke research.

Conclusions:

  • Improving the design of preclinical studies and clinical trials is crucial for successful translation of stroke cell therapies.
  • Standardized protocols and adherence to industry recommendations can bridge the gap between animal research and patient benefit.
  • Future research must focus on optimizing experimental designs to yield more predictive and clinically relevant outcomes for stroke therapeutics.