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Whole genome approaches in ischemic stroke
1Department of Neurology, Mayo Clinic, 4500 San Pablo Road, Jacksonville, FL 32224, USA. meschia.james@mayo.edu
Stroke
|December 10, 2008
Summary
Genomewide association studies (GWAS) show promise for identifying genetic factors in ischemic stroke. However, a pilot study found no single major gene, highlighting the need for larger, more powerful research.
Area of Science:
- Genetics
- Neurology
- Genomics
Background:
- Ischemic stroke genetics research is transitioning from candidate gene studies to genomewide association studies (GWAS).
- GWAS have proven effective in identifying genetic factors for various complex disorders.
Purpose of the Study:
- To review the application and potential of GWAS in understanding the genetic basis of ischemic stroke.
- To assess the current state of genetic discovery in ischemic stroke.
Main Methods:
- Informal qualitative review of peer-reviewed medical literature.
- Analysis of existing GWAS findings in complex diseases and pilot studies in ischemic stroke.
Main Results:
- GWAS have successfully identified genetic associations in type 2 diabetes mellitus.
- A pilot GWAS for ischemic stroke did not detect any single gene with a major effect on disease risk.
Conclusions:
- Larger-scale GWAS with increased statistical power are crucial for advancing ischemic stroke genetics.
- Future research initiatives, including those by the Wellcome Trust, are planned to address this need.
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