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Identification of Sleeping Beauty Transposon Insertions in Solid Tumors using Linker-mediated PCR
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A DNA transposon-based approach to validate oncogenic mutations in the mouse

Qin Su1, Haydn M Prosser, Lia S Campos

  • 1Wellcome Trust Sanger Institute, Hinxton, Cambridge CB10 1HH, England.

Proceedings of the National Academy of Sciences of the United States of America
|December 10, 2008
PubMed
Summary

Researchers developed a novel DNA transposon platform to test cancer gene functions in mice. This system enables early tumor development, aiding the study of genetic mutations in human cancer.

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