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Navigating MARRVEL, a Web-Based Tool that Integrates Human Genomics and Model Organism Genetics Information

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Genotype-phenotype databases: challenges and solutions for the post-genomic era.

Gudmundur A Thorisson¹, Juha Muilu, Anthony J Brookes

¹Department of Genetics, University of Leicester, University Road, Leicester LE1 7RH, UK.

Nature Reviews. Genetics

|December 10, 2008

Summary

This summary is machine-generated.

Managing the increasing complexity of genetic data for health and disease requires advanced informatics tools. New systems enhance data management and retrieval, creating a powerful knowledge environment for genotype-phenotype information.

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Area of Science:

Genomics and Bioinformatics
Health Informatics

Background:

Research data on the genetic basis of health and disease is rapidly increasing in volume and complexity.
Existing data management solutions like central databases and manual curation face challenges with this data deluge.

Purpose of the Study:

To outline advancements in informatics tools and systems for managing and exploiting genetic research data.
To describe how new approaches enhance the creation of a genotype-phenotype knowledge environment.

Main Methods:

Enhancing traditional solutions like central databases with federated databases and database publication.
Implementing automated management for data flows and quality control.
Leveraging emerging technologies for improved connectivity and data retrieval.

Main Results:

New systems offer more efficient and automated management of large-scale genetic datasets.
Federated databases and automated quality control improve data accessibility and reliability.
Emerging technologies enhance the integration and retrieval of genotype-phenotype information.

Conclusions:

Advanced informatics tools and systems are crucial for managing the growing complexity of genetic research data.
These innovations facilitate a more powerful and interconnected knowledge environment for genotype-phenotype information.
The integration of new technologies promises to significantly advance our understanding of the genetic basis of health and disease.