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Updated: Jun 27, 2026

A Murine Model of Stent Implantation in the Carotid Artery for the Study of Restenosis

A Murine Model of Stent Implantation in the Carotid Artery for the Study of Restenosis

Published on: May 14, 2013

Restenosis begets restenosis: implications for stent selection.

J S Wijpkema¹, R L Anthonio, G A J Jessurun

¹Department of Cardiology, Thoraxcenter, University Medical Center Groningen, the Netherlands.

Netherlands Heart Journal : Monthly Journal of the Netherlands Society of Cardiology and the Netherlands Heart Foundation

|December 10, 2008

Summary

This summary is machine-generated.

A history of clinical recurrence (CR) after percutaneous coronary intervention (PCI) significantly increases the risk of future CR in different coronary arteries. This finding aids stent selection for patients undergoing PCI.

Keywords:

angioplasty coronary artery disease drug-eluting stents percutaneous coronary intervention restenosis

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Last Updated: Jun 27, 2026

A Murine Model of Stent Implantation in the Carotid Artery for the Study of Restenosis

A Murine Model of Stent Implantation in the Carotid Artery for the Study of Restenosis

Published on: May 14, 2013

Area of Science:

Cardiology
Interventional Cardiology
Vascular Medicine

Background:

Restenosis risk identification is crucial for percutaneous coronary intervention (PCI) stent selection.
Previous clinical recurrence (CR) after PCI may predict future events in other coronary arteries.

Purpose of the Study:

To evaluate if a history of CR after PCI increases the risk of CR following treatment of a de novo lesion in a different coronary artery.

Main Methods:

Retrospective analysis of 12,763 patients undergoing PCI (1993-2004).
Selection of 1010 patients with interventions in at least two different native vessels.
Comparison of CR rates between patients with and without prior CR.

Main Results:

Patients with prior CR had a 3.4-fold increased risk of CR after a second intervention (OR=3.4, 95% CI=2.3-4.9).
CR rates after a third intervention were 50% (two prior CR), 17% (one prior CR), and 3% (no prior CR) (p<0.001).

Conclusions:

A history of CR is a strong predictor of future CR in different coronary arteries.
CR history serves as a simple, powerful tool for guiding stent selection (bare metal vs. drug-eluting stents).