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Related Experiment Video

Updated: Jun 27, 2026

Techniques for the Analysis of Extracellular Vesicles Using Flow Cytometry
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Techniques for the Analysis of Extracellular Vesicles Using Flow Cytometry

Published on: March 17, 2015

Characterizing blood microparticles: technical aspects and challenges.

Arun S Shet1

  • 1Department of Medicine, St. Johns Medical College and Hospital, St. Johns National Academy of Health Sciences, Bangalore, India. arunshet@iphcr.res.in

Vascular Health and Risk Management
|December 11, 2008
PubMed
Summary

Microparticles (MPs), once thought to be debris, now reflect cell activity. This review focuses on technical methods for studying blood microparticles, emphasizing preanalytical and analytical factors.

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Area of Science:

  • Hematology
  • Cell Biology
  • Biochemistry

Background:

  • Microparticles (MPs) were historically dismissed as cellular debris.
  • Recent research identifies MPs as indicators of cellular stimulation, activation, and apoptosis.
  • Blood MPs originate from blood cells and the vascular endothelium.

Purpose of the Study:

  • To review methodologies for studying blood microparticles.
  • To highlight technical aspects of characterizing MP morphology and function.
  • To emphasize the importance of preanalytical and analytical variables in MP research.

Main Methods:

  • Review of various techniques employed by different research groups.
  • Focus on methods for assessing morphological properties.
  • Emphasis on functional characterization approaches.

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Last Updated: Jun 27, 2026

Techniques for the Analysis of Extracellular Vesicles Using Flow Cytometry
09:39

Techniques for the Analysis of Extracellular Vesicles Using Flow Cytometry

Published on: March 17, 2015

Routine Screening Method for Microparticles in Platelet Transfusions
09:49

Routine Screening Method for Microparticles in Platelet Transfusions

Published on: January 31, 2018

Micro-particle Image Velocimetry for Velocity Profile Measurements of Micro Blood Flows
07:53

Micro-particle Image Velocimetry for Velocity Profile Measurements of Micro Blood Flows

Published on: April 25, 2013

Main Results:

  • Blood MPs are defined as small (< or = 1.5 microm) particles.
  • Blood MPs expose phosphatidylserine (PS) on their outer membrane.
  • MPs bear surface antigens indicating their cellular origin.

Conclusions:

  • Standardized technical approaches are crucial for reliable blood MP characterization.
  • Understanding preanalytical and analytical variables is key to accurate MP studies.
  • Blood MPs offer valuable insights into cellular states and vascular health.