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Updated: Jun 27, 2026

Preparation and Characterization of Nanoliposomes for the Entrapment of Bioactive Hydrophilic Globular Proteins
Published on: August 31, 2019
[Pharmaceutical characteristics of brucine stealth liposomes]
Jun Chen1, Wei Wang, Bao-chang Cai
1College of Pharmacy, Nanjing University of Chinese Medicine, Nanjing 210029, China.
Objective:
To prepare brucine stealth liposomes and compare the in vitro characteristics with brucine conventional liposomes.
Method:
Brucine stealth liposomes and conventional liposomes were both prepared by ammonium sulfate transmembrane gradients. The encapsulation efficiency, particle size, in vitro release profiles and stability were compared respectively.
Result:
The encapsulation efficiency of brucine stealth liposomes and conventional liposomes were (80.7 +/- 0.5)%, and (80.5 +/- 0.3)%, respectively. The mean paricle sizes were 103.5 nm and 169. 4 nm, respectively. Whether rat plasma was added or not, the release rate and degree of brucine stealth liposomes were significantly lower than those of conventional liposomes. Brucine stealth liposomes were more stable than conventional liposomes.
Conclusion:
As the antitumor durg delivery system, the in vitro characteristics of brucine stealth liposomes are more satisfactory than the corresponding conventional liposomes.
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