Related Experiment Video
Updated: Jun 27, 2026

Yeast Luminometric and Xenopus Oocyte Electrophysiological Examinations of the Molecular Mechanosensitivity of TRPV4
Published on: December 31, 2013
Expression of the osmotically responsive cationic channel TRPV4 in the endolymphatic sac
H Kumagami1, M Terakado, Y Sainoo
1Department of Otolaryngology, Nagasaki University, Sakamoto 1-7-1, Nagasaki 852-8501, Japan. kumagami@nagasaki-u.ac.jp
Abstract:
The immunohistochemical expression pattern and the physiological role of transient receptor potential vanilloid (TRPV) 4 in the endolymphatic sac were investigated. TRPV4 was expressed predominantly in the apical membrane of mitochondria-rich cells, and cell volume regulation by TRPV4 was observed in a tissue culture of the rat endolymphatic sac. TRPV4 was also present in the endolymphatic sacs of patients with vestibular schwannoma and with Ménière's disease. TRPV4 is assumed to play a role as an osmoreceptor in cell and fluid volume regulation in the human endolymphatic sac.
Related Concept Videos
Mechanically-gated Ion Channels
Ion Channels
Ion channels are specialized integral membrane proteins on the plasma membrane that allow specific...
Anatomy of the Ear
Overview of Secretory Vesicles
Various proteins regulate the aggregation of molecules inside the secretory vesicles. Chromogranins...
Thermosensation
G-Protein Gated Ion Channels
Sensory organs,...

