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Published on: May 31, 2016
Fatigue in low-grade glioma
Karin Struik1, Martin Klein, Jan J Heimans
1Department of Neurology, VU University Medical Center, P.O. Box 7057, 1007 MB, Amsterdam, The Netherlands.
Journal of Neuro-Oncology
|December 11, 2008
Summary
Many long-term low-grade glioma (LGG) survivors experience severe fatigue. This fatigue is linked to antiepileptic drug use and decreased cognitive function, particularly in older patients.
Area of Science:
- Neuro-oncology
- Clinical Psychology
Background:
- Low-grade gliomas (LGG) are primary brain tumors with a generally favorable prognosis.
- Long-term survivors of LGG often face chronic health issues, including significant fatigue.
Purpose of the Study:
- To determine the prevalence and severity of fatigue in long-term LGG survivors.
- To analyze factors associated with fatigue, including demographics, tumor characteristics, treatment, and medication use.
Main Methods:
- A cohort of 54 long-term LGG survivors (diagnosed >8 years prior) with stable disease was assessed.
- Fatigue was evaluated using the Checklist Individual Strength (CIS).
- Statistical analyses explored correlations between fatigue and various clinical and demographic variables.
Main Results:
- 39% of LGG patients reported severe fatigue, with older age being a significant factor.
- Severe fatigue was associated with antiepileptic drug (AED) use and reduced self-reported concentration, motivation, and activity.
- No significant associations were found between fatigue and gender, histology, tumor location, disease duration, or specific treatments.
Conclusions:
- Fatigue is a prevalent and severe issue impacting a substantial portion of long-term LGG survivors.
- Identifying and managing fatigue, particularly in relation to AEDs and cognitive function, is crucial for improving quality of life in this population.
