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An Unpredictable Chronic Mild Stress Protocol for Instigating Depressive Symptoms, Behavioral Changes and Negative Health Outcomes in Rodents
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Published on: December 2, 2015

Depression and cardiovascular disease.

A Glassman1

  • 1Department of Psychiatry, Columbia University College of Physicians and 14 Surgeons, New York, USA. ahg1@columbia.edu

Pharmacopsychiatry
|December 11, 2008
PubMed
Summary
This summary is machine-generated.

This review shows depression increases mortality risk, but treating it may reduce this risk. Further research is needed to confirm the benefits of antidepressants for cardiovascular health.

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A Middle Cerebral Artery Occlusion Technique for Inducing Post-stroke Depression in Rats
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A Middle Cerebral Artery Occlusion Technique for Inducing Post-stroke Depression in Rats

Published on: May 22, 2019

Area of Science:

  • Cardiology
  • Psychiatry
  • Epidemiology

Background:

  • The link between depression and mortality has been historically challenging to establish scientifically.
  • Early research focused on Type A personality as a mortality risk predictor, but this evidence later weakened.
  • Focus shifted to depression as a predictor, with a 25-year period before the association was firmly established.

Purpose of the Study:

  • To review evidence linking depression to increased mortality risk.
  • To explore the potential of depression treatment in reducing mortality.
  • To examine the association between depression and cardiovascular disease (CVD).

Main Methods:

  • Review of epidemiological studies on depression and mortality in healthy individuals and CVD patients.
  • Examination of research on post-myocardial infarction (MI) depression.
  • Analysis of data on the safety and efficacy of antidepressant treatments, particularly SSRIs.

Main Results:

  • Depression is firmly established as a predictor of mortality, especially in patients with cardiovascular disease.
  • Evidence suggests Selective Serotonin Reuptake Inhibitor (SSRI) antidepressants are safe and effective for depression.
  • There is a suggestion that SSRIs may reduce adverse medical events, but this is not definitive.

Conclusions:

  • Depression is a significant risk factor for mortality, particularly in cardiovascular patients.
  • While SSRIs appear safe and effective, definitive evidence of their impact on reducing cardiovascular morbidity and mortality is still needed.
  • The underlying mechanisms connecting depression, cardiovascular morbidity, and mortality remain uncertain.