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Semi-Minimal Invasive Method to Induce Myocardial Infarction in Rats and the Assessment of Cardiac Function by an Isolated Working Heart System
Published on: June 11, 2020
Development of a new semi-quantitative non-invasive method for evaluating ventricular stroke work
Mu-Hua Cheng1, Guo-Hui Rao, Han-Jian Zhou
1Department of Nuclear medicine, Third Hospital Affiliated Sun Yat-sen University, Guangdong Province, China. marka@21c.com
Clinical Physiology and Functional Imaging
|December 11, 2008
Summary
A new non-invasive method estimates ventricular stroke work (SW) using relative stroke work (RSW). This approach correlates well with invasive SW measurements and shows potential for evaluating ventricular function in patients.
Area of Science:
- Cardiology
- Medical Imaging
- Biophysics
Background:
- Ventricular stroke work (SW) is a key index for assessing ventricular function.
- Current SW monitoring relies on invasive arterial catheterization.
- A non-invasive method is needed to evaluate ventricular SW.
Purpose of the Study:
- To develop a novel semi-quantitative, non-invasive method for evaluating ventricular SW.
- Introduce relative stroke work (RSW) as a new parameter.
Main Methods:
- Multiple gated cardiac blood pool imaging in 25 coronary artery disease patients and 12 controls.
- Calculated left ventricular relative stroke work (RSW) using hydrodynamic principles.
- Analyzed SW with stroke volume (SV) and mean arterial pressure; assessed ejection fraction (EF), peak ejected rate (PER), and peak filling rate (PFR).
Main Results:
- Left ventricular RSW showed a linear correlation with SW.
- RSW demonstrated relationships with SV, EF, PER, and PFR.
- RSW, SW, SV, EF, PFR, and PER were significantly lower in patients compared to controls (P<0.01).
Conclusions:
- Relative stroke work (RSW) is a promising clinical index for ventricular function assessment.
- The developed non-invasive method offers a valuable alternative to invasive SW monitoring.
