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Related Concept Videos

Skin Cancer01:30

Skin Cancer

Skin cancer is a type of cancer that occurs when there is an abnormal growth of skin cells, usually triggered by damage to the DNA within the skin cells. It is primarily caused by exposure to ultraviolet (UV) radiation from the sun or artificial sources like tanning beds. Skin cancer is the most common type of cancer worldwide, and its incidence continues to rise.
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Pigmentation01:19

Pigmentation

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Skin Diseases and Disorders01:23

Skin Diseases and Disorders

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Papillary Dermis01:11

Papillary Dermis

Dermis
The dermis might be considered the "core" of the integumentary system, as distinct from the epidermis and hypodermis. It contains blood and lymph vessels, nerves, and other structures, such as hair follicles and sweat glands. The dermis is made of two layers of connective tissue that comprise an interconnected mesh of elastin and collagenous fibers, produced by fibroblasts.
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Changes in Skin Color: Clinical Perspectives01:14

Changes in Skin Color: Clinical Perspectives

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Reticular Dermis

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Eccrine nevus presenting as a hypopigmented patch.

Hania Salama1, Tor Shwayder

  • 1Wayne State University School of Medicine, Detroit, Michigan, USA.

Pediatric Dermatology
|December 11, 2008
PubMed
Summary
This summary is machine-generated.

A rare skin condition, eccrine nevus, presented uniquely in a young child. This hamartoma caused a hypopigmented patch with increased sweating on his trunk.

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Area of Science:

  • Dermatology
  • Pediatric Pathology
  • Medical Genetics

Background:

  • Eccrine nevi are rare benign hamartomas originating from eccrine sweat glands.
  • They typically present as congenital or early-onset lesions, often with characteristic features.
  • Understanding the diverse presentations of eccrine nevi is crucial for accurate diagnosis and management.

Observation:

  • A 14-month-old Caucasian male exhibited a distinct hypopigmented patch.
  • The affected area, located on the right back, flank, and abdomen, also displayed increased perspiration.
  • This truncal distribution and pale coloration represented an unusual clinical manifestation.

Findings:

  • Diagnostic investigations, including the starch-iodide test and subsequent biopsy, confirmed the presence of an eccrine nevus.
  • The starch-iodide test highlighted areas of anhidrosis or hyperhidrosis, aiding in the localization of eccrine gland dysfunction.
  • Histopathological examination revealed the characteristic features of a hamartoma derived from eccrine structures.

Implications:

  • This case underscores the variability in the clinical presentation of eccrine nevi, particularly regarding their location and appearance.
  • The unique truncal and hypopigmented manifestation highlights the importance of considering rare diagnoses in pediatric dermatology.
  • Further research into the genetic and developmental pathways of eccrine hamartomas may elucidate the mechanisms behind such atypical presentations.