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Updated: Jun 27, 2026
Facile Preparation of Internally Self-assembled Lipid Particles Stabilized by Carbon Nanotubes
Published on: February 19, 2016
Biodistribution and clearance of instilled carbon nanotubes in rat lung
Dan Elgrabli1, Magali Floriani, Steve Abella-Gallart
1Institut National de l'Environnement Industriel et des Risques (INERIS), Verneuil en Halatte, France. dan.elgrabli@ineris.fr.
Background:
Constituted only by carbon atoms, CNT are hydrophobic and hardly detectable in biological tissues. These properties make biokinetics and toxicology studies more complex.
Methods:
We propose here a method to investigate the biopersistence of CNT in organism, based on detection of nickel, a metal present in the MWCNT we investigated.
Results And Conclusion:
Our results in rats that received MWCNT by intratracheal instillation, reveal that MWCNT can be eliminated and do not significantly cross the pulmonary barrier but are still present in lungs 6 months after a unique instillation. MWCNT structure was also showed to be chemically modified and cleaved in the lung. These results provide the first data of CNT biopersistence and clearance at 6 months after respiratory administration.
