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Related Concept Videos

McNemar's Test01:23

McNemar's Test

McNemar's Test is a nonparametric statistical test used to determine if there is a significant difference in proportions between two related groups when the outcome is binary (e.g., yes/no, success/failure). It is beneficial when we have paired data, such as pre-test/post-test designs, where the same subjects are measured under two different conditions. The test is named after the statistician Quinn McNemar, who introduced it in 1947. It is commonly used in situations where subjects are...
z Scores and Area Under the Curve01:17

z Scores and Area Under the Curve

z scores are the standardized values obtained after converting a normal distribution into a standard normal distribution. A z score is measured in units of the standard deviation. The z score tells you how many standard deviations the value x is above (to the right of) or below (to the left of) the mean, μ. Values of x that are larger than the mean have positive z scores, and values of x that are smaller than the mean have negative z scores. If x equals the mean, then x has a z score of zero.

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A Quick Phenotypic Neurological Scoring System for Evaluating Disease Progression in the SOD1-G93A Mouse Model of ALS
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[Gleason's score: update in 2008].

Vincent Molinié1

  • 1Service de pathologie, groupe hospitalier Paris Saint-Joseph, 185, rue Raymond-Losserand, 75014 Paris cedex, France. vmolinie@hpsj.fr

Annales De Pathologie
|December 11, 2008
PubMed
Summary
This summary is machine-generated.

The Gleason grading system for prostate cancer, established in 1966, is still vital for communication between pathologists and urologists. This article details the 2005 International Society of Uropathology modifications to this essential prostate cancer score.

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Area of Science:

  • Uropathology
  • Oncology
  • Histopathology

Context:

  • The Gleason grading system, introduced in 1966, has been a cornerstone in prostate cancer diagnosis and communication for over four decades.
  • It facilitates essential dialogue between pathologists and urologists regarding cancer progression and treatment strategies.

Purpose:

  • To present the key modifications to the Gleason score introduced in 2005 by the International Society of Uropathology.
  • To highlight updates in prostate cancer histological grading.

Summary:

  • The original Gleason score, a widely adopted system for grading prostate cancer histology, has undergone significant revisions.
  • The International Society of Uropathology proposed modifications in 2005 to refine the accuracy and clinical utility of prostate cancer grading.

Impact:

  • These modifications aim to enhance the precision of prostate cancer assessment.
  • Updated grading systems improve risk stratification and inform therapeutic decisions in prostate cancer management.